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Validation of Multivariate Outlier Detection Analyses Used to Identify Potential Drug-Induced Liver Injury in Clinical Trial Populations

Author
XIWU LIN1 ; PARKS, Daniel1 ; PAINTER, Jeffery2 ; HUNT, Christine M3 ; STIRNADEL-FARRANT, Heide A4 ; JIE CHENG1 ; MENIUS, Alan2 ; LEE, Kwan1
[1] Medical Analytics, GlaxoSmithKline, Collegeville, PA, United States
[2] Medical Analytics, GlaxoSmithKline, Research Triangle Park, NC, United States
[3] Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Research Triangle Park, NC, United States
[4] Worldwide Epidemiology, GlaxoSmithKline, Stockley Park, United Kingdom
Source

Drug safety. 2012, Vol 35, Num 10, pp 865-875, 11 p ; ref : 24 ref

ISSN
0114-5916
Scientific domain
Pharmacology drugs; Toxicology
Publisher
Adis International, Auckland
Publication country
New Zealand
Document type
Article
Language
English
Keyword (fr)
Analyse multivariable Diagnostic Détection Essai clinique Foie Homme Médicament Seuil détection Toxicité Validation Pathologie de l'appareil digestif Pathologie du foie
Keyword (en)
Multivariate analysis Diagnosis Detection Clinical trial Liver Human Drug Detection threshold Toxicity Validation Digestive diseases Hepatic disease
Keyword (es)
Análisis multivariable Diagnóstico Detección Ensayo clínico Hígado Hombre Medicamento Umbral detección Toxicidad Validación Aparato digestivo patología Hígado patología
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U04 Toxicity: digestive system

Discipline
Drugs toxicity and drug intoxications Toxicology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
26369636

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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