Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture
- Author
- FRANCQUE, Sven1 2 ; LALEMAN, Wim3 ; DE WINTER, Benedicte2 ; VAN MARCK, Eric8 ; VAN MARCK, Veerle8 ; PELCKMANS, Paul1 2 ; MICHIELSEN, Peter1 2 ; VERBEKE, Len3 ; VAN STEENKISTE, Christophe4 ; CASTELEYN, Christophe5 ; KWANTEN, Wilhelmus2 ; VAN DYCK, Christophe2 ; D'HONDT, Michiel2 ; RAMON, Albert1 6 7 ; VERMEULEN, Wim2
[1] Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
[2] Laboratory of Experimental Medicine and Paediatrics, Division of Gastroenterology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
[3] Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
[4] Department of Hepatology, Ghent University Hospital, Ghent, Belgium
[5] Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
[6] ITERA (International Tissue Engineering Research Association) Life Sciences Forum, Lanaken, Belgium
[7] Genetisch-Diagnostisches Labor, Köln, Germany
[8] Laboratory of Pathology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium - Source
Laboratory investigation. 2012, Vol 92, Num 10, pp 1428-1439, 12 p ; ref : 45 ref
- CODEN
- LAINAW
- ISSN
- 0023-6837
- Scientific domain
- Biochemistry, molecular biology, biophysics; Medical laboratory techniques; General medicine general surgery
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- NAFLD endothelial dysfunction in situ perfusion intrahepatic resistance morphological alterations portal hypertension
- Keyword (fr)
- Architecture Biologie clinique Biotechnologie Endothélium Grave Hypertension portale In situ Intrahépatique Microcirculation Morphologie Perfusion Résistance Stéatose Trouble fonctionnel Dysfonction endothéliale Pathologie de l'appareil circulatoire Pathologie de l'appareil digestif Pathologie de la circulation portale Pathologie des vaisseaux sanguins
- Keyword (en)
- Architecture Clinical biology Biotechnology Endothelium Severe Portal hypertension In situ Intrahepatic Microcirculation Morphology Perfusion Resistance Steatosis Dysfunction Endothelial dysfunction Cardiovascular disease Digestive diseases Portal circulation disease Vascular disease
- Keyword (es)
- Arquitectura Biología clínica Biotecnología Endotelio Grave Hipertensión portal In situ Intrahepático Microcirculación Morfología Perfusión Resistencia Esteatosis Trastorno funcional Disfunción del endotelio Aparato circulatorio patología Aparato digestivo patología Circulación portal patología Vaso sanguíneo patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C03 Other diseases. Semiology
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B24 Investigative techniques, diagnostic techniques (general aspects)
- Discipline
- Biotechnology Gastroenterology. Liver. Pancreas. Abdomen Scanning and diagnostic techniques
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26494174
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/labinvest.2012.103 
https://dx.doi.org/10.1038/labinvest.2012.103
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