Targeted Multiplex Imaging Mass Spectrometry with Single Chain Fragment Variable (scfv) Recombinant Antibodies

Author

THIERY, Gwendoline^{1 2 4} ; MERNAUGH, Ray L² ; HEPING YAN^{2 5} ; SPRAGGINS, Jeffrey M^{1 2} ; JUNHAI YANG^{1 2} ; PARL, Fritz F³ ; CAPRIOLI, Richard M^{1 2}
[1] Mass Spectrometry Research Center, School of Medicine, Vanderbilt University, Nashville, TN, United States
[2] Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN, United States
[3] Department of Pathology, School of Medicine, Vanderbilt University, Nashville, TN, United States
[4] National Resource for Imaging Mass Spectrometry (NRIMS), Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 65 Landsdowne St, Cambridge, MA, United States
[5] School of Medicine, Washington University in St. Louis, St. Louis, MO, United States

Source

Journal of the American Society for Mass Spectrometry. 2012, Vol 23, Num 10, pp 1689-1696, 8 p ; ref : 20 ref

ISSN

1044-0305

Scientific domain

Biochemistry, molecular biology, biophysics; Analytical chemistry; Organic chemistry

Publisher

Elsevier, Amsterdam

Publication country

Netherlands

Document type

Article

Language

English

Author keyword

Imaging mass spectrometry Immunohistochemistry Laser desorption ionization mass spectrometry Single chain fragment variable recombinant antibodies Targeted multiplex imaging mass spectrometry

Keyword (fr)

Anticorps monoclonal Anticorps simple chaîne Avidine Biotinylation Cancer du sein Composé conjugué Cytochrome P450 Drug-metabolizing enzyme Désorption laser En parallèle Fragment Glande mammaire Immunohistochimie Isozyme Mesure simultanée Multiplexage Méthode immunoenzymatique Photoionisation Spectrométrie masse Technique ELISA Tissu Unspecific monooxygenase Cytochrome CYP1A1 Cytochrome CYP1B1 Imagerie spectrométrie masse Cancer Enzyme Oxidoreductases Tumeur maligne

Keyword (en)

Monoclonal antibody Single chain antibody Avidin Biotinylation Breast cancer Conjugated compound Cytochrome P450 Drug-metabolizing enzyme Laser desorption Parallel Fragment Mammary gland Immunohistochemistry Isozyme Simultaneous measurement Multiplexing Enzyme immunoassay Photoionization Mass spectrometry ELISA assay Tissue Unspecific monooxygenase Imaging mass spectrometry Cancer Enzyme Oxidoreductases Malignant tumor

Keyword (es)

Anticuerpo monoclonal Anticuerpo simple cadena Avidina Biotinilacion Cáncer del pecho Compuesto conjugado Citocromo P450 Drug-metabolizing enzyme Desorción láser En paralelo Fragmento Glándula mamaria Inmunohistoquímica Isozima Medición simultánea Multiplaje Método inmunoenzimático Fotoionización Espectrometría masa Técnica ELISA Tejido Unspecific monooxygenase Cáncer Enzima Oxidoreductases Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A06 Fundamental immunology / 002A06B Molecular immunology / 002A06B06 Techniques

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04F Host-tumor relations. Immunology. Biological markers

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B24 Investigative techniques, diagnostic techniques (general aspects) / 002B24O Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques / 002B24O11 Genital system. Mammary gland

Discipline

Fundamental immunology Scanning and diagnostic techniques Tumours

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

26507158

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS