High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responses
- Author
- METZELDER, S. K1 ; SCHROEDER, T2 ; HEINICKE, T11 ; STUHLMANN, R12 ; MÜLLER, L13 ; GIAGOUNIDIS, A14 ; MEYER, R. G15 ; BRUGGER, W16 ; VÖHRINGER, M17 ; DREGER, P18 ; MORI, M19 20 ; BASARA, N21 ; FINCK, A3 ; SCHÄFER-ECKART, K22 ; SCHULTHEIS, B23 ; BALDUS, C24 ; NEUBAUER, A1 ; BURCHERT, A1 ; SCHOLL, S4 ; FEY, M5 ; GÖTZE, K6 ; LINN, Y. C7 ; KRÖGER, M8 ; REITER, A9 ; SALIH, H. R10
[1] Philipps Universitat Marburg, Universitätsklinikum Giessen und Marburg, Standort Marburg, Klinik fur Hämatologie, Onkologie und Immunologie, Marburg, Germany
[2] Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
[3] Department of Hematology/Oncology, University of Freiburg, Freiburg, Germany
[4] Universitätsklinikum Jena, Abteilung für Hämatologie/Onkologie, Jena, Germany
[5] Department of Medical Oncology, Inselspital and University of Bern, Bern, Switzerland
[6] Department of Internal Medicine III, Technische Univerisitat München, Munchen, Germany
[7] Department of Hematology, Singapore General Hospital, Singapore, Singapore
[8] Onkologische Schwerpunktpraxis Bremerhaven, Bremerhaven, Germany
[9] Universitätsmedizin Mannheim, III. Medizinische Klinik, Mannheim, Germany
[10] Department of Hematology/Oncology, Eberhard Karls-University Tübingen, Tübingen, Germany
[11] Otto-von-Guericke-Universität Magdeburg, Klinik für Hämatologie/ Onkologie, Magdeburg, Germany
[12] Asklepios Klinik St. Georg, Abteilung für Hämatologie, Onkologie und Stammzelltransplantation, Hamburg, Germany
[13] Onkologische Schwerpunktpraxis Leer-Emden, Leer-Emden, Germany
[14] St Johannes Hospital, Medizinische Klinik 2, Duisburg, Germany
[15] Department of Hematology, Oncology, and Pneumology, University Medical Center Mainz, Mainz, Germany
[16] Schwarzwald-Baar Klinikum, Klinik für Hämatologie/Onkologie, Villingen-Schwenningen, Germany
[17] Robert-Bosch-Krankenhaus, Abteilung fur Hämatologie, Onkologie und Klinische Immunologie, Stuttgart, Germany
[18] Department of Medicine, University of Heidelberg, Heidelberg, Germany
[19] Department of Hematology and Oncology, University of Vermont, Burlington, VT, United States
[20] Department of Palliative Medicine, Seirei Hamamatsu General Hospital, Shizuoka, Japan
[21] Department of Hematology, Oncology and Hemostaseology, University Clinical Center, Leipzig, Germany
[22] Klinikum Nurnberg, Medizinische Klinik 5, Medizinische Onkologie, Hämatologie und Stammzelltransplantation, Nürnberg, Germany
[23] Depatment of Hematology/Oncology, Marienhospital Herne, Ruhr-University Bochum, Herne, Germany
[24] Department of Hematology and Oncology, Charité, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany - Source
Leukemia. 2012, Vol 26, Num 11, pp 2353-2359, 7 p ; ref : 36 ref
- CODEN
- LEUKED
- ISSN
- 0887-6924
- Scientific domain
- Medical oncology; Hematology
- Publisher
- Nature Publishing Group, Avenel, NJ
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- AML FLT3-ITD sorafenib stem cell transplantation
- Keyword (fr)
- Activité biologique Antiangiogénique Anticancéreux Cellule hématopoïétique Cellule souche Gène onc cellulaire Hématologie Leucémie aiguë myéloblastique Protooncogène Récepteur trk Réponse immune Sorafénib Duplication interne en tandem Greffe de cellules souches hématopoïétiques Gène FLT3 Cancer Hémopathie maligne Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase
- Keyword (en)
- Biological activity Antiangiogenic agent Antineoplastic agent Hematopoietic cell Stem cell C-Onc gene Hematology Acute myelogenous leukemia Protooncogene trk receptor Immune response Sorafenib Internal tandem duplication Hematopoietic stem cell transplantation FLT3 gene Cancer Malignant hemopathy Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor
- Keyword (es)
- Actividad biológica Antiangiogenico Anticanceroso Célula hematopoyética Célula primitiva Gen onc celular Hematología Leucemia aguda mieloblástica Protooncogen Receptor trk Respuesta inmune Sorafenib Injerto de célula primitiva hematopoyética Cáncer Hemopatía maligna Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26597827
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/leu.2012.105 
https://dx.doi.org/10.1038/leu.2012.105
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