Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
- Author
- KULIS, Marta1 ; HEATH, Simon2 ; BARBERAN-SOLER, Sergio7 ; PAPASAIKAS, Panagiotis7 ; JARES, Pedro1 ; BEA, Silvia1 ; RICO, Daniel8 ; ECKER, Simone8 ; RUBIO, Miriam8 ; R, Romina9 ; HO, Vincent3 ; KLOTZLE, Brandy3 ; BIBIKOVA, Marina3 ; HERNANDEZ, Lluis1 ; CONDE, Laura1 ; LOPEZ-GUERRA, Mónica1 ; COLOMER, Dolors1 ; VILLAMOR, Neus1 ; AYMERICH, Marta1 ; ROZMAN, Maria1 ; BAYES, Mónica2 ; GUT, Marta2 ; GELPI, Josep L9 ; QUEIROS, Ana C4 ; OROZCO, Modesto9 ; FAN, Jian-Bing3 ; QUESADA, Victor10 ; PUENTE, Xose S10 ; PISANO, David G8 ; VALENCIA, Alfonso8 ; LOPEZ-GUILLERMO, Armando5 ; GUT, Ivo2 ; LOPEZ-OTIN, Carlos10 ; CAMPO, Elias1 ; NAVARRO, Alba1 ; MARTIN-SUBERO, Jose I4 ; CLOT, Guillem1 ; MARTINEZ-TRILLOS, Alejandra5 ; CASTELLANO, Giancarlo1 ; BRUN-HEATH, Isabelle2 ; PINYOL, Magda6
[1] Unidad de Hematopatologla, Servicio de Anatomia Patológica, Hospital Clinic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
[2] Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
[3] Illumina, Inc., San Diego, California, United States
[4] Departamento de Anatomia Patológica, Farmacología y Microbiología, Universitat de Barcelona, Barcelona, Spain
[5] Servicio de Hematología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
[6] Unidad de Genómica, IDIBAPS, Barcelona, Spain
[7] Centre de Regulacló Genòmica, Universitat Pompeu Fabra, Barcelona, Spain
[8] Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
[9] Joint Program on Computational Biology, Barcelona Supercomputing Center (BSC) and Institute of Research in Biomedicine (IRB), Barcelona Science Park, Barcelona, Spain
[10] Departamento de Bioquimica y Biología Molecular, Instituto Universitario de Oncologia (IUOPA), Universidad de Oviedo, Oviedo, Spain - Source
Nature genetics. 2012, Vol 44, Num 11, pp 1236-1242, 7 p ; ref : 34 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- DNA Epigénétique Gène Leucémie lymphoïde chronique Méthylation Cancer Hémopathie maligne Syndrome lymphoprolifératif
- Keyword (en)
- DNA Epigenetics Gene Chronic lymphocytic leukemia Methylation Cancer Malignant hemopathy Lymphoproliferative syndrome
- Keyword (es)
- DNA Epigenética Gen Leucemia linfoidea crónica Metilación Cáncer Hemopatía maligna Linfoproliferativo síndrome
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Eukaryotes genetics. Biological and molecular evolution
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26624072
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.2443 
https://dx.doi.org/10.1038/ng.2443
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arXiv access
