Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
- Author
- LAFAILLE, Fabien G1 2 ; PESSACH, Itai M3 4 ; ORDOVAS-MONTANES, Jose3 ; JOUANGUY, Emmanuelle5 6 ; PLANCOULAINE, Sabine6 ; TU, Edmund1 2 ; ELKABETZ, Yechiel10 ; AL-MUHSEN, Saleh11 ; TARDIEU, Marc12 ; SCHLAEGER, Thorsten M13 ; DALEY, George Q13 ; ABEL, Laurent5 6 ; ZHANG, Shen-Ying5 6 ; CASANOVA, Jean-Laurent14 5 6 ; STUDER, Lorenz1 2 ; NOTARANGELO, Luigi D15 3 ; CIANCANELLI, Michael J5 ; MERMAN, Melina5 6 ; ABHYANKAR, Avinash5 ; YING, Shui-Wang7 ; KEROS, Sotirios8 ; GOLDSTEIN, Peter A7 ; MOSTOSLAVSKY, Gustavo9
[1] Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, New York 10065, United States
[2] Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, New York 10065, United States
[3] Division of Immunology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States
[4] The Talpiot Medical Leadership Program, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 52621, Israel
[5] St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, New York 10065, United States
[6] Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France
[7] C.V. Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Cornell Medical College, New York, New York 10065, United States
[8] Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medical College, New York, New York 10065, United States
[9] Section of Gastroenterology, Department of Medicine and Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, Massachusetts 02118, United States
[10] Laboratory for Pluripotent and Neural Stem Cell Biology, Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
[11] Prince Naif Center for Immunology Research, Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
[12] Department of Pediatric Neurology, Assistance Publique-Hôpitaux de Paris, Bicetre Hospital, Kremlin-Bicêtre, 94275, France
[13] Division of Pediatric Hematology/ Oncology, Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States
[14] Pediatric Hematology-Immunology Unit, Necker Hospital, Paris 75015, France
[15] The Manton Center for Orphan Disease Research, Children's Hospital, Boston, Massachusetts 02115, United States - Source
Nature (London). 2012, Vol 491, Num 7426, pp 769-773, 5 p ; ref : 30 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Encéphalite Herpesvirus hominis 1 Homme Neurone Oligodendrocyte Pathogénie Récepteur TLR3 Récepteur biologique Système nerveux central Virose Cellule souche pluripotente induite Immuniité intrinsèque Alphaherpesvirinae Herpesviridae Infection Névroglie Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Virus
- Keyword (en)
- Encephalitis Human herpesvirus 1 Human Neuron Oligodendrocyte Pathogenesis Toll like receptor 3 Biological receptor Central nervous system Viral disease Induced pluripotent stem cell Intrinsic immunity Alphaherpesvirinae Herpesviridae Infection Neuroglia Cerebral disorder Central nervous system disease Nervous system diseases Virus
- Keyword (es)
- Encefalitis Herpesvirus hominis 1 Hombre Neurona Oligodendrocito Patogenia Receptor TLR3 Receptor biológico Sistema nervioso central Virosis Célula primitiva pluripotencial inducida Inmunidad intrínseca Alphaherpesvirinae Herpesviridae Infección Neuroglia Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases
- Discipline
- Infectious pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26635266
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature11583 
https://dx.doi.org/10.1038/nature11583
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