Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial

Auteur

BISSLER, John J¹ ; CHRISTOPHER KINGSWOOD, J² ; WHITTEMORE, Vicky H¹¹ ; CHEN, David¹² ; SAHMOUD, Tarek¹² ; SHAH, Gaurav¹² ; LINCY, Jeremie¹³ ; LEBWOHL, David¹² ; BUDDE, Klemens⁹ ; RADZIKOWSKA, Elżbteta³ ; ZONNENBERG, Bernard A⁴ ; FROST, Michael⁵ ; BELOUSOVA, Elena⁶ ; SAUTER, Matthias⁷ ; NONOMURA, Norio⁸ ; BRAKEMEIER, Susanne⁹ ; DE VRIES, Petrus J¹⁰
[1] Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
[2] Royal Sussex County Hospital, Brighton, United Kingdom
[3] National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
[4] Universitair Medisch Centrum, Utrecht, Netherlands
[5] Minnesota Epilepsy Group, St Paul, MN, United States
[6] Moscow Research Institute of Pediatrics & Pediatric Surgery, Moscow, Russian Federation
[7] Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
[8] Osaka University Hospital, Osaka, Japan
[9] Charite Universitätsmedizin, Berlin, Germany
[10] Division of Child & Adolescent Psychiatry, University of Cape Town, South Africa
[11] National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
[12] Novartis Pharmaceuticals Corporation, Florham Park, NJ, United States
[13] Novartis Pharmaceuticals Corporation, Basel, Switzerland

Source

Lancet (British edition). 2013, Vol 381, Num 9869, pp 817-824, 8 p ; ref : 30 ref

CODEN

LANCAO

ISSN

0140-6736

Domaine scientifique

General medicine general surgery

Editeur

Elsevier, Kidlington

Pays de publication

United Kingdom

Type de document

Article

Langue

Russian

Mot clé (fr)

Angiomyolipome Antibactérien Association Complexe Complexité Essai clinique Etude double insu Etude multicentrique Evérolimus Immunodépresseur Médecine Phacomatose de Bourneville Sporadique Essai randomisé contrôlé Inhibiteur mTOR Lymphangiomyomatose Inhibiteur synthèse protéique Lactone Macrolide Maladie héréditaire Pathologie du système nerveux Tumeur

Mot clé (en)

Angiomyolipoma Antibacterial agent Association Complexes Complexity Clinical trial Double blind study Multicenter study Everolimus Immunosuppressive agent Medicine Bourneville syndrome Sporadic Randomized controlled trial Lymphangiomyomatosis Protein synthesis inhibitor Lactone Macrolide Genetic disease Nervous system diseases Tumor

Mot clé (es)

Angiomiolipoma Antibacteriano Asociación Complejo Complejidad Ensayo clínico Estudio doble ciego Estudio multicéntrico Everolimus Inmunodepresor Medicina Facomatosis Bourneville Esporádico Ensayo aleatorio controlado Inhibidor síntesis proteica Lactona Macrólido Enfermedad hereditaria Sistema nervioso patología Tumor

Classification

Pascal

002 Sciences biologiques et medicales / 002B Sciences medicales / 002B01 Generalites

Pascal

002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S02 Antibactériens

Pascal

002 Sciences biologiques et medicales / 002B Sciences medicales / 002B17 Neurologie / 002B17E Tumeurs du système nerveux. Phacomatoses

Discipline

Generalities in medical sciences Neurology Pharmacological treatments

Provenance

Inist-CNRS

Base de données

PASCAL

Identifiant INIST

27042633

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS