Effects of Hepatic Impairment on the Pharmacokinetics of Everolimus: A Single-Dose, Open-Label, Parallel-Group Study
- Author
- PEVELING-OBERHAG, Jan1 ; ZEUZEM, Stefan1 ; WEI PENGYONG2 ; KUNZ, Tiffany3 ; PAQUET, Thierry4 ; BOUILLAUD, Emmanuel4 ; URVA, Shweta5 ; ANAK, Oezlem4 ; SELLAMI, Dalila5 ; KOBALAVA, Zhanna6
[1] JW Goethe University Hospital, Frankfurt, Germany
[2] National University Cancer Institute Singapore, Singapore
[3] Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, United States
[4] Novartis Pharma AG, Basel, Switzerland
[5] Novartis Pharmaceuticals Corporation, Florham Park, New Jersey, United States
[6] Peoples' Friendship University of Russia, Moscow, Russian Federation - Source
Clinical therapeutics. 2013, Vol 35, Num 3, pp 215-225, 11 p ; ref : 20 ref
- ISSN
- 0149-2918
- Scientific domain
- Pharmacology drugs
- Publisher
- Elsevier, Bridgewater, NJ
- Publication country
- United States
- Document type
- Article
- Language
- Russian
- Author keyword
- healthy subjects hepatic impairment molecular therapeutics pharmacokinetics
- Keyword (fr)
- Dose unique Evérolimus Homme Immunodépresseur Individu sain Insuffisance hépatique Pharmacocinétique Traitement Inhibiteur mTOR Inhibiteur synthèse protéique Lactone Macrolide Pathologie de l'appareil digestif Pathologie du foie
- Keyword (en)
- Single dose Everolimus Human Immunosuppressive agent Healthy subject Liver failure Pharmacokinetics Treatment Protein synthesis inhibitor Lactone Macrolide Digestive diseases Hepatic disease
- Keyword (es)
- Dosis única Everolimus Hombre Inmunodepresor Individuo sano Insuficiencia hepática Farmacocinética Tratamiento Inhibidor síntesis proteica Lactona Macrólido Aparato digestivo patología Hígado patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C03 Other diseases. Semiology
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27200312
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.clinthera.2013.02.007 
https://dx.doi.org/10.1016/j.clinthera.2013.02.007
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