RAS―MAPK―MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Author

JEEHYE PARK^{1 2 3} ; AL-RAMAHI, Ismael^{1 2} ; YOONTAE LEE^{1 2 3} ; JAFAR-NEJAD, Paymaan^{1 2} ; SAYEGH, Layal S^{1 2} ; RICHMAN, Ronald^{1 2 3} ; XIUYUN LIU^{1 2 3} ; YAN GAO^{1 2} ; SHAW, Chad A¹ ; ARTHUR, J. Simon C⁷ ; ORR, Harry T^{4 5} ; WESTBROOK, Thomas F^{1 6 8} ; QIUMIN TAN^{1 2 3} ; BOTAS, Juan^{1 2} ; ZOGHBI, Huda Y^{1 2 3 6} ; MOLLEMA, Nissa^{4 5} ; DIAZ-GARCIA, Javier R^{1 2} ; GALLEGO-FLORES, Tatiana^{1 2} ; LU, Hsiang-Chih^{2 6} ; LAGALWAR, Sarita^{4 5} ; DUVICK, Lisa^{4 5} ; HYOJIN KANG^{1 2}
[1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, United States
[2] Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, United States
[3] Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, United States
[4] Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States
[5] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, United States
[6] Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, United States
[7] MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
[8] Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, United States

Source

Nature (London). 2013, Vol 498, Num 7454, pp 325-331, 7 p ; ref : 47 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Mitogen-activated protein kinase Protéine Toxicité Enzyme Transferases

Keyword (en)

Mitogen-activated protein kinase Protein Toxicity Enzyme Transferases

Keyword (es)

Mitogen-activated protein kinase Proteína Toxicidad Enzima Transferases

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A25 Vertebrates: nervous system and sense organs

Discipline

Vertebrates : nervous system and sense organs

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

27605659

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS