Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma
- Author
- CAMIDGE, D. Ross1 ; BLAIS, Normand2 ; CHOW, Laura Q3 ; JONKER, Derek J3 ; SOULIERES, Denis2 ; DOEBELE, Robert C1 ; RUIZ-GARCIA, Ana4 ; THALL, Aron4 ; KE ZHANG4 ; LAURIE, Scott A3 ; CHAO, Richard C4
[1] University of Colorado Cancer Center, Mail Stop F704, 1665 Aurora Court, ACP Room 2256, Aurora, CO 80045, United States
[2] Centre de Lutte Contre le Cancer du CHUM, Montreal, Canada
[3] The Ottawa Hospital Cancer Centre, Ottawa, Canada
[4] Pfizer Oncology, La Jolla, CA, United States - Source
Cancer chemotherapy and pharmacology. 2013, Vol 71, Num 2, pp 307-319, 13 p ; ref : 32 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Cisplatin NSCLC Pemetrexed Phase I Solid tumors Sunitinib
- Keyword (fr)
- Antiangiogénique Anticancéreux Cancer du poumon Carcinome non petite cellule bronchopulmonaire Cisplatine Dose croissante Etude cohorte Homme Malignité Mésothéliome Pharmacocinétique Pémétrexed Santé publique Stade avancé Sunitinib Tumeur maligne Tumeur solide Escalade de dose Agent alkylant Antifolate Cancer Enzyme Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Platine II Complexe Protein-tyrosine kinase Transferases
- Keyword (en)
- Antiangiogenic agent Antineoplastic agent Lung cancer non-small cell lung carcinoma Cisplatin Increasing dose Cohort study Human Malignancy Mesothelioma Pharmacokinetics Pemetrexed Public health Advanced stage Sunitinib Malignant tumor Solid tumor Dose escalation Alkylating agent Antifolate Cancer Enzyme Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Respiratory disease Bronchus disease Lung disease Platinum II Complexes Protein-tyrosine kinase Transferases
- Keyword (es)
- Antiangiogenico Anticanceroso Cáncer del pulmón Carcinoma no pequeňa célula bronchopulmonar Cisplatino Dosis creciente Estudio cohorte Hombre Malignidad Mesotelioma Farmacocinética Pemetrexed Salud pública Estadio avanzado Sunitinib Tumor maligno Tumor sólido Agente alquilante Antifolato Cáncer Enzima Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Aparato respiratorio patología Bronquio patología Pulmón patología Platino II Complejo Protein-tyrosine kinase Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11A Tumors of the respiratory system and mediastinum
- Discipline
- Pharmacological treatments Pulmonology Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27614535
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-012-2008-6 
https://dx.doi.org/10.1007/s00280-012-2008-6
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