P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents
- Author
- O'BRIEN, Fionn E1 2 3 ; O'CONNOR, Richard M3 ; CLARKE, Gerard1 4 ; DINAN, Timothy G1 4 ; GRIFFIN, Brendan T2 ; CRYAN, John F1 3
[1] Alimentary Pharmabiotic Center, University College Cork, Cork, Ireland
[2] Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland
[3] Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
[4] Department of Psychiatry, University College Cork, Cork, Ireland - Source
Neuropsychopharmacology (New York, NY). 2013, Vol 38, Num 11, pp 2209-2219, 11 p ; ref : 1 p.1/2
- CODEN
- NEROEW
- ISSN
- 0893-133X
- Scientific domain
- Cognition; Neurology; Pharmacology drugs; Psychology, psychopathology, psychiatry
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- P-glycoprotein antidepressant blood―brain barrier escitalopram microdialysis treatment-resistant depression
- Keyword (fr)
- Activité Animal Antidépresseur Barrière hématoencéphalique Distribution Encéphale Escitalopram Etat dépressif Glycoprotéine P Inhibition Psychotrope Rodentia Résistance traitement Inhibiteur recapture Inhibiteur sélectif recapture sérotonine Mammalia Neurotransmetteur Pharmacocinétique Système nerveux central Sérotonine Trouble de l'humeur Vertebrata
- Keyword (en)
- Activity Animal Antidepressant agent Blood brain barrier Distribution Encephalon Escitalopram Depression P Glycoprotein Inhibition Psychotropic Rodentia Treatment resistance Reuptake inhibitor Selective serotonin reuptake inhibitor Mammalia Neurotransmitter Pharmacokinetics Central nervous system Serotonin Mood disorder Vertebrata
- Keyword (es)
- Actividad Animal Antidepresor Barrera hematoencefálica Distribución Encéfalo Escitalopram Estado depresivo Glicoproteína P Inhibición Psicotropo Rodentia Resistencia tratamiento Inhibidor recaptura Inhibidor selectivo recaptura serotonin Mammalia Neurotransmisor Farmacocinética Sistema nervioso central Serotonina Trastorno humor Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C07 Mood disorders / 002B18C07A Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03G Mood disorders / 770-D03G01 Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 27795689
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/npp.2013.120 
https://dx.doi.org/10.1038/npp.2013.120
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