Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
- Author
- FITZGERALD, Kevin1 ; FRANK-KAMENETSKY, Maria1 ; NOCHUR, Saraswathy V1 ; KOTELIANSKI, Victor1 ; HORTON, Jay2 ; MANT, Timothy3 ; CHIESA, Joseph4 ; RITTER, James3 ; MUNISAMY, Malathy4 ; VAISHNAW, Akshay K1 ; GOLLOB, Jared A1 ; SIMON, Amy1 ; SHULGA-MORSKAYA, Svetlana1 ; LIEBOW, Abigail1 ; BETTENCOURT, Brian R1 ; SUTHERLAND, Jessica E1 ; HUTABARAT, Renta M1 ; CLAUSEN, Valerie A1 ; KARSTEN, Verena1 ; CEHELSKY, Jeffrey1
[1] Alnylam Pharmaceuticals, Cambridge, MA, United States
[2] Internal Medicine and Molecular Genetics, University of Texas South Western, Dallas, TX, United States
[3] Quintiles Drug Research Unit at Guy's Hospital, London, United Kingdom
[4] Covance Clinical Research Unit, Leeds, United Kingdom - Source
Lancet (British edition). 2014, Vol 383, Num 9911, pp 60-68, 9 p ; ref : 39 ref
- CODEN
- LANCAO
- ISSN
- 0140-6736
- Scientific domain
- General medicine general surgery
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cholestérol LDL Concentration Essai clinique phase I Essai clinique Individu sain Interférence ARN Kexin Médecine Médicament Placebo Randomisation Subtilisin Synthèse RNA Sérum Enzyme Hydrolases Peptidases Serine endopeptidases Silence expression génique
- Keyword (en)
- Cholesterol LDL Concentration Phase I trial Clinical trial Healthy subject RNA interference Kexin Medicine Drug Placebo Randomization Subtilisin RNA synthesis Serum Enzyme Hydrolases Peptidases Serine endopeptidases Gene silencing
- Keyword (es)
- Colesterol LDL Concentración Ensayo clínico fase I Ensayo clínico Individuo sano ARN interferencia Kexin Medicina Medicamento Placebo Aleatorización Subtilisin Síntesis RNA Suero Enzima Hydrolases Peptidases Serine endopeptidases Silencio expresión genética
- Classification
- Discipline
- Generalities in medical sciences
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 28036945
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0140-6736(13)61914-5 
https://dx.doi.org/10.1016/S0140-6736(13)61914-5
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