The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index
- Author
- WALSH, Michael1 2 3 ; SRINATHAN, Sadeesh K4 ; THABANE, Lehana1 ; WALTER, Stephen D1 2 ; POGUE, Janice1 3 ; DEVEREAUX, P. J1 2 3 ; MCAULEY, Daniel F5 6 ; MRKOBRADA, Marko7 ; LEVINE, Oren2 ; RIBIC, Christine1 2 ; MOLNAR, Amber O8 ; DATTANI, Neil D9 ; BURKE, Andrew7 ; GUYATT, Gordon1 2
[1] Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4L8, Canada
[2] Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4L8, Canada
[3] Population Health Research Institute, Hamilton Health Sciences and McMaster University, 237 Barton St East, Hamilton, Ontario L8L2X2, Canada
[4] Department of Surgery, University of Manitoba, Health Sciences Centre, GE611 Sherhrooke St., Winnipeg, Manitoba R3AIR9, Canada
[5] Centre for Infection and Immunity, Queen's University of Belfast, Health Sciences Building, 97 Lisbum Road, Belfast, BT97BL, United Kingdom
[6] Regional Intensive Care Unit, Royal Victoria Hospital, Victoria Hospital, 274 Grosvenor Road, Belfast, BTI26BA, United Kingdom
[7] Department of Medicine, Western University, London Health Sciences Centre, University Hospital, 339 Windemere Road, London, Ontario N6A 5A5, Canada
[8] Department of Medicine, University of Ottawa, Ottawa Hospital, Riverside Campus, 1967 Riverside Drive, Ottawa, Ontario KIH7W9, Canada
[9] Faculty of Medicine, University of Toronto, Medical Sciences Building, I Kings College Circle, Toronto, Ontario M5S1A8, Canada - Source
Journal of clinical epidemiology. 2014, Vol 67, Num 6, pp 622-628, 7 p ; ref : 13 ref
- ISSN
- 0895-4356
- Scientific domain
- General medicine general surgery
- Publisher
- Elsevier, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Lost to follow-up Randomized controlled trials Research methodology
- Keyword (fr)
- Epidémiologie Essai clinique Indice Médecine Méthodologie Randomisation Recherche scientifique Résultat Santé publique Statistique Essai randomisé contrôlé Perdu de vue
- Keyword (en)
- Epidemiology Clinical trial Index Medicine Methodology Randomization Scientific research Result Public health Statistics Randomized controlled trial
- Keyword (es)
- Epidemiología Ensayo clínico Indice Medicina Metodología Aleatorización Investigación científica Resultado Salud pública Estadística Ensayo aleatorio controlado
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B30 Public health. Hygiene-occupational medicine / 002B30A Public health. Hygiene / 002B30A01 General aspects / 002B30A01A Epidemiology / 002B30A01A1 Methodology
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B30 Public health. Hygiene-occupational medicine / 002B30A Public health. Hygiene / 002B30A01 General aspects / 002B30A01A Epidemiology / 002B30A01A2 Analysis. Health state
- Discipline
- Generalities in medical sciences Public health. Hygiene-occupational medicine
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 28525765
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.jclinepi.2013.10.019 
https://dx.doi.org/10.1016/j.jclinepi.2013.10.019
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