Risperidone metabolic ratio as a biomarker of individual CYP2D6 genotype in schizophrenic patients
- Author
- MANNHEIMER, Buster1 ; HOLM, Johan2 ; KOUKEL, Larissa2 ; BERTILSSON, Leif2 ; ÖSBY, Urban3 4 ; ELIASSON, Erik2
[1] Karolinska Institutet, Department of Clinical Science and Education at Södersjukhuset, Stockholm, Sweden
[2] Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
[3] Department of Molecular Medicine and Surgery, Neurogenetics Unit, and Centre for Molecular Medicine, Stockholm, Sweden
[4] Department of Psychiatry, Tiohundra AB, Norrtälje, Sweden - Source
European journal of clinical pharmacology. 2014, Vol 70, Num 6, pp 695-699, 5 p ; ref : 23 ref
- ISSN
- 0031-6970
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- CYP2D6 genotype Genetic polymorphism Psychotropic drugs Therapeutic drug monitoring
- Keyword (fr)
- Antipsychotique atypique Cytochrome P450 Génotype Homme Isozyme Marqueur biologique Médicament Métabolisme Polymorphisme Psychotrope Rispéridone Schizophrénie Suivi thérapeutique pharmacologique Variabilité génétique Cytochrome CYP2D6 Cytochrome P4502D6 Antagoniste dopamine Antagoniste sérotonine Benzisoxazole dérivé Enzyme Neuroleptique Pharmacocinétique Psychose Récepteur dopaminergique D2 Récepteur sérotoninergique
- Keyword (en)
- Atypical antipsychotic Cytochrome P450 Genotype Human Isozyme Biological marker Drug Metabolism Polymorphism Psychotropic Risperidone Schizophrenia Therapeutic drug monitoring Genetic variability Cytochrome CYP2D6 Dopamine antagonist Serotonin antagonist Benzisoxazole derivatives Enzyme Neuroleptic Pharmacokinetics Psychosis D2 Dopamine receptor Serotonine receptor
- Keyword (es)
- Antipsicótico atípico Citocromo P450 Genotipo Hombre Isozima Marcador biológico Medicamento Metabolismo Polimorfismo Psicotropo Risperidona Esquizofrenia Monitorización farmacoterapéutica Variabilidad genética Antagonista dopamina Antagonista serotonina Benzisoxazol derivado Enzima Neuroléptico Farmacocinética Psicosis Receptor dopaminérgico D2 Receptor serotoninérgico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C06 Psychoses / 002B18C06A Schizophrenia
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03F Psychoses / 770-D03F01 Schizophrenia
- Discipline
- General pharmacology Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 28598544
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00228-014-1664-3 
https://dx.doi.org/10.1007/s00228-014-1664-3
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