Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
- Auteur
- WOONDONG JEONG1 ; RAPISARDA, Annamaria2 ; KUMMAR, Shivaani1 3 ; SOOK RYUN PARK1 ; KINDERS, Robert J2 ; CHEN, Alice1 ; MELILLO, Giovanni2 ; TURKBEY, Baris3 ; STEINBERG, Seth M3 ; CHOYKE, Peter3 ; DOROSHOW, James H1 3
[1] Division of Cancer Treatment and Diagnosis. National Cancer Institute, Bethesda, MD 20892, United States
[2] Leidos Biomedical Research. Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States
[3] Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, United States - Source
Cancer chemotherapy and pharmacology. 2014, Vol 73, Num 2, pp 343-348, 6 p ; ref : 20 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Domaine scientifique
- Medical oncology; Pharmacology drugs
- Editeur
- Springer, Heidelberg
- Pays de publication
- Germany
- Type de document
- Article
- Langue
- English
- Mot clé auteur
- Antiangiogenesis HIF mRNA Pharmacodynamics-driven trials Synthetic locked nucleic acid (LNA) oligodeoxynucleotide
- Mot clé (fr)
- Activité biologique Antiangiogénique Essai clinique Facteur transcription HIF1 Homme Inhibiteur Oligodésoxyribonucléotide Oligonucléotide antisens Produit synthétique RNA messager Résistance traitement Tumeur solide Acide nucléique verrouillé Pharmacodynamie Cancer Tumeur maligne
- Mot clé (en)
- Biological activity Antiangiogenic agent Clinical trial Transcription factor HIF1 Human Inhibitor Oligodeoxyribonucleotide Antisense oligonucleotide Synthetic product Messenger RNA Treatment resistance Solid tumor Locked Nucleic Acid Pharmacodynamics Cancer Malignant tumor
- Mot clé (es)
- Actividad biológica Antiangiogenico Ensayo clínico Factor transcripción HIF1 Hombre Inhibidor Oligodesoxirribonucleótido Oligonucleótido antisentido Producto sintético RNA mensajero Resistencia tratamiento Tumor sólido Ácido nucleic bloqueado Farmacodinámica Cáncer Tumor maligno
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02R Anticancéreux
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B04 Tumeurs / 002B04C Tumeurs multiples. Tumeurs solides. Tumeurs chez l'enfant (généralités)
- Discipline
- Pharmacological treatments Tumours
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 28599960
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-013-2362-z 
https://dx.doi.org/10.1007/s00280-013-2362-z
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