PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines
- Author
- IZETTI, Patricia1 2 3 ; HAUTEFEUILLE, Agnes4 ; HAINAUT, Pierre11 ; ASHTON-PROLLA, Patricia1 12 2 ; ABUJAMRA, Ana Lucia3 5 6 ; DE FARIAS, Caroline Brunetto3 5 6 ; GIACOMAZZI, Juliana1 ; ALEMAR, Bárbara1 2 ; LENZ, Guido7 ; ROESLER, Rafael3 6 8 ; SCHWARTSMANN, Gilberto3 6 9 ; OSVALDT, Alessandro Bersch10
[1] Laboratório de Medicina Genômica, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[2] Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500-Prédio 43323M, Porto Alegre 91501-970, RS, Brazil
[3] Laboratório de Pesquisas em Câncer, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[4] International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69372, France
[5] Instituto do Câncer Infantil do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[6] Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[7] Laboratório de Sinalização e Plasticidade Celular, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500-Prédio 43431, Porto Alegre 91501-970, RS, Brazil
[8] Laboratório de Neurofarmacologia e Biologia de Tumores Neurais, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500-Sala 211, Porto Alegre 91501-970, RS, Brazil
[9] Serviço de Oncologia Clínica, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[10] Serviçe de Cirurgia do Aparelho Digestivo, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-003, RS, Brazil
[11] International Prevention Research Institute, 95 Cours Lafayette, Lyon 69006, France
[12] Departamento de Genética, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500-Prédio 43323M, Porto Alegre 91501-970, RS, Brazil - Source
Investigational new drugs. 2014, Vol 32, Num 5, pp 783-794, 12 p ; ref : 38 ref
- CODEN
- INNDDK
- ISSN
- 0167-6997
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Apoptosis PRIMA-1 Pancreatic cancer p53
- Keyword (fr)
- Apoptose Cancer du pancréas Cellule tumorale Chimiothérapie Cytotoxicité Gène TP53 Gène suppresseur tumeur In vitro Lignée cellulaire établie Mort cellulaire Mutation Gène p53 Cancer Pathologie de l'appareil digestif Pathologie du pancréas Traitement Tumeur maligne
- Keyword (en)
- Apoptosis Pancreas cancer Tumor cell Chemotherapy Cytotoxicity TP53 Gene Tumor suppressor gene In vitro Established cell line Cell death Mutation Cancer Digestive diseases Pancreatic disease Treatment Malignant tumor
- Keyword (es)
- Apoptosis Cáncer del páncreas Célula tumoral Quimioterapia Citotoxicidad Gen TP53 Gen supresor tumor In vitro Línea celular establecida Muerte celular Mutación Cáncer Aparato digestivo patología Páncreas patología Tratamiento Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 28891037
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s10637-014-0090-9 
https://dx.doi.org/10.1007/s10637-014-0090-9
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