Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial

Author

BAETEN, Jared M^{1 2 3} ; DONNELL, Deborah^{1 6} ; KATABIRA, Elly¹⁴ ; RONALD, Allan¹⁵ ; TUMWESIGYE, Elioda¹⁶ ; WERE, Edwin¹⁷ ; FIFE, Kenneth H¹⁸ ; KIARIE, James^{1 12} ; FARQUHAR, Carey^{1 2 3} ; JOHN-STEWART, Grace^{1 2 3 5} ; KIDOGUCHI, Lara¹ ; COOMBS, Robert W^{2 4} ; MUGO, Nelly R^{1 7} ; HENDRIX, Craig¹⁹ ; MARZINKE, Mark A¹⁹ ; FRENKEL, Lisa^{20 4 5} ; HABERER, Jessica E^{21 22} ; BANGSBERG, David²¹ ; CELUM, Connie^{1 3} ; NDASE, Patrick¹ ; THOMAS, Katherine K¹ ; CAMPBELL, James D⁹ ; WANGISI, Jonathan¹⁰ ; TAPPERO, Jordan W¹¹ ; BUKUSI, Elizabeth A^{1 13 8} ; COHEN, Craig R¹³
[1] Department of Global Health, University of Washington, Seattle, WA, United States
[2] Department of Medicine, University of Washington, Seattle, WA, United States
[3] Department of Epidemiology, University of Washington, Seattle, WA, United States
[4] Department of Laboratory Medicine, University of Washington, Seattle, WA, United States
[5] Department of Pediatrics, University of Washington, Seattle, WA, United States
[6] Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States
[7] Centres for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya
[8] Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
[9] Centers for Disease Control and Prevention, Entebbe, Uganda
[10] AIDS Support Organization, Kampala, Uganda
[11] Centers for Disease Control and Prevention, Atlanta, GA, United States
[12] Department of Obstetrics and Gynecology, University of Nairobi and Kenyatta National Hospital, Nairobi, Kenya
[13] Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, United States
[14] Infectious Disease Institute, Makerere University, Kampala, Uganda
[15] Department of Medicine, University of Manitoba, Winnipeg, Canada
[16] Kabwohe Clinical Research Center, Kabwohe, Uganda
[17] Department of Reproductive Health, Moi University, Eldoret, Kenya
[18] Department of Medicine, Indiana University, Indianapolis, IN, United States
[19] Department of Medicine, Johns Hopkins University, Baltimore, MD, United States
[20] Seattle Children's Hospital Research Institute, Seattle, WA, United States
[21] Massachusetts General Hospital, Boston, MA, United States
[22] Harvard Medical School, Boston, MA, United States
Partners PrEP Study Team

Source

Lancet. Infectious diseases (print). 2014, Vol 14, Num 11, pp 1055-1064, 10 p ; ref : 30 ref

ISSN

1473-3099

Scientific domain

General medicine general surgery; Microbiology, infectious diseases

Publisher

Lancet Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Antirétroviral Antiviral Association médicamenteuse Emtricitabine Etude comparative Prévention SIDA Ténofovir Virus HIV1 Analogue de nucléoside Analogue de nucléotide Enzyme Immunodéficit Immunopathologie Infection Inhibiteur enzyme Inhibiteur reverse transcriptase Lentivirus Nucleotidyltransferases Nucléotide acyclique Phosphonate organique Purine nucléotide RNA-directed DNA polymerase Retroviridae Transferases Virose Virus immunodéficience humaine Virus

Keyword (en)

Antiretroviral agent Antiviral Drug combination Emtricitabine Comparative study Prevention AIDS Tenofovir HIV-1 virus Nucleoside analog Nucleotide analog Enzyme Immune deficiency Immunopathology Infection Enzyme inhibitor Reverse transcriptase inhibitor Lentivirus Nucleotidyltransferases Acyclic nucleotide Organic phosphonate Purine nucleotide RNA-directed DNA polymerase Retroviridae Transferases Viral disease Human immunodeficiency virus Virus

Keyword (es)

Antiretroviral Antiviral Asociación medicamentosa Emtricitabina Estudio comparativo Prevención SIDA Tenofovir HIV-1 virus Análogo nucleósido Análogo nucléotido Enzima Inmunodeficiencia Inmunopatología Infección Inhibidor enzima Inhibitor reverse transcriptase Lentivirus Nucleotidyltransferases Nucleótido acíclico Fosfonato orgánico Purina nucleótido RNA-directed DNA polymerase Retroviridae Transferases Virosis Human immunodeficiency virus Virus

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02D Viral diseases of the lymphoid tissue and the blood. Aids

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D01 Immunodeficiencies

Discipline

Immunopathology Infectious pathology Pharmacological treatments

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

28893578

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS