Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues
- Author
- LESCHKE, C1 ; SIGURD ELZ1 ; GARBARG, M2 ; SCHUNACK, W1
[1] Freie Univ. Berlin, inst. pharmacology, 14195 Berlin, Germany
[2] INSERM, cent. Paul Broca, unité neurobiologie pharmacologie, 75014 Paris, France - Source
Journal of medicinal chemistry (Print). 1995, Vol 38, Num 8, pp 1287-1294 ; ref : 50 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agoniste Amine primaire Animal Cobaye Fixation biologique Histamine Hétérocycle azote Imidazole dérivé In vitro In vivo Intestin Relation structure activité Récepteur histaminergique H1 Souris Synthèse chimique Système nerveux central Sélectivité Vaisseau sanguin Imidazole(4-[2-aminoéthyl]-2-aryl) Imidazole(4-[2-aminoéthyl]-2-hétéryl) Mammalia Rodentia Vertebrata
- Keyword (en)
- Agonist Primary amine Animal Guinea pig Biological fixation Histamine Nitrogen heterocycle Imidazole derivatives In vitro In vivo Gut Structure activity relation H1 receptor Mouse Chemical synthesis Central nervous system Selectivity Blood vessel Mammalia Rodentia Vertebrata
- Keyword (es)
- Agonista Amina primaria Animal Cobayo Fijación biológica Histamina Heterociclo nitrógeno Imidazol derivado In vitro In vivo Intestino Relación estructura actividad Receptor histaminérgico H1 Ratón Síntesis química Sistema nervioso central Selectividad Vaso sanguíneo Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3517507
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00008a007 
https://dx.doi.org/10.1021/jm00008a007
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