1,2,4-triazolo[4,3-a]pyrozine derivatives with human inhibitory activity. 2.1 synthesis, biological properties and molecular modeling of hydroxyethylene isostere derivatives
- Author
- BRADBURY, R. H; MAJOR, J. S; OLDHAM, A. A; RIVETT, J. E; ROBERTS, D. A; SLATER, A. M; TIMMS, D; WATERSON, D
ICI Pharmaceuticals, dep. chemistry biosci., Cheshire SK10 4TG, United Kingdom - Source
Journal of medicinal chemistry (Print). 1990, Vol 33, Num 9, pp 2335-2342 ; ref : 26 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Aminoalcool Carboxamide Composé cyclique Cycle 6 chaînons Hétérocycle azote angulaire Hétérocycle azote Inhibiteur enzyme Pseudopeptide Relation structure activité Renin Caproïque acide(5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl) butylamide Triazolo pyrazine dérivé Enzyme
- Keyword (en)
- Aminoalcohol Carboxamide Cyclic compound Six membered ring Angular nitrogen heterocycle Nitrogen heterocycle Enzyme inhibitor Pseudopeptide Structure activity relation Renin Enzyme
- Keyword (es)
- Aminoalcohol Carboxamida Compuesto cíclico Ciclo 6 eslabones Heterociclo nitrógeno angular Heterociclo nitrógeno Inhibidor enzima Seudopéptido Relación estructura actividad Renin Enzima
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 5233020
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00171a006 
https://dx.doi.org/10.1021/jm00171a006
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