In vitro human tissue models in risk assessment : Report of a consensus-building workshop

Author

MACGREGOR, James T¹ ; COLLINS, Jerry M¹ ; KEDDERIS, Gregory L¹⁰ ; KRISHNAN, Kannan¹¹ ; LI, Albert P¹² ; PARCHMENT, Ralph E¹³ ; THUMMEL, Kenneth¹⁴ ; TOMASZEWSKI, Joseph E¹⁵ ; ULRICH, Roger¹⁶ ; VICKERS, Alison E. M¹⁷ ; WRIGHTON, Steven A¹⁸ ; SUGIYAMA, Yuichi² ; TYSON, Charles A³ ; DEAN, Jack⁴ ; SMITH, Lewis⁵ ; ANDERSEN, Melvin⁶ ; CURREN, Rodger D⁷ ; HOUSTON, J. Brian⁸ ; KADLUBAR, Fred F⁹
[1] Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States
[2] Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan, Japan
[3] SRI International, Menlo Park, California, United States
[4] Sanofi Synthelabo, Inc., Malvern, Pennsylvania, United States
[5] Zeneca Pharmaceuticals, Alderly Park, United Kingdom
[6] Colorado State University, Center for Environmental Toxicology and Technology, Fort Collins, Colorado, United States
[7] Institute for in Vitro Sciences, Gaithersburg, Maryland, United States
[8] School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
[9] National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States
[10] Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, United States
[11] Université de Montréal, Santé Environnementale et Santé au Travail, Montréal, Québec, Canada
[12] In vitro Technologies, Inc., Baltimore, Maryland, United States
[13] Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States
[14] University of Washington, Department of Pharmaceutics, Seattle, Washington, United States
[15] National Cancer Institute, Toxicology and Pharmacology Branch, Rockville, Maryland, United States
[16] Abbott Laboratories, Abbott Park, Illinois, United States
[17] Novartis Institute for Biomedical Research, Department of Preclinical Safety, East Hanover, New Jersey, United States
[18] Eli Lilly & Company, Indianapolis, Indiana, United States

Source

Toxicological sciences (Print). 2001, Vol 59, Num 1, pp 17-36 ; ref : 3 p

CODEN

TOSCF2

ISSN

1096-6080

Scientific domain

Toxicology

Publisher

Oxford University Press, Cary, NC

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Comparaison interspécifique Déterminisme génétique Foie Homme Hépatocyte In vitro Interaction médicamenteuse Modèle PBPK Métabolisme Pharmacocinétique Polymorphisme Prédiction Toxicité Toxicocinétique

Keyword (en)

Interspecific comparison Genetic determinism Liver Human Hepatocyte In vitro Drug interaction Physiologically based pharmacokinetic model Metabolism Pharmacokinetics Polymorphism Prediction Toxicity Toxicokinetics

Keyword (es)

Comparación interespecífica Determinismo genético Hígado Hombre Hepatocito In vitro Interacción medicamentosa PBPK modelo Metabolismo Farmacocinética Polimorfismo Predicción Toxicidad Toxicocinética

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology / 002B03A General aspects. Methods

Discipline

Toxicology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

1011507

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS