Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
- Author
- SITTLER, Annie1 ; LURZ, Rudi1 ; LUEDER, Gerhild2 ; PRILLER, Josef3 ; HAYER-HARTL, Manajit K2 ; HARTL, F. Ulrich2 ; LEHRACH, Hans1 ; WANKER, Erich E1
[1] Max-Planck Institut für Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
[2] Max-Planck Institut für Biochemie, Abt. Zelluläre Biochemie, Am Klopferspitz 18A, 82152 Martinsried, Germany
[3] Department of Neurology, Charité, Humboldt-University, Schumannstrasse 20-21, 10117 Berlin, Germany - Source
Human molecular genetics (Print). 2001, Vol 10, Num 12, pp 1307-1315 ; ref : 38 ref
- Publisher
- Oxford University Press, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agrégation Benzoquinone dérivé Chorée Huntington Expression génique Homme Huntingtine Induction Protéine choc thermique Rein Singe Traitement Geldanamycine Lignée COS1 Encéphale pathologie Extrapyramidal syndrome Lignée cellulaire Maladie dégénérative Maladie héréditaire Mammalia Primates Système nerveux central pathologie Système nerveux pathologie Vertebrata
- Keyword (en)
- Aggregation Benzoquinone derivatives Huntington disease Gene expression Human Huntingtin Induction Heat shock protein Kidney Monkey Treatment Cerebral disorder Extrapyramidal syndrome Cell line Degenerative disease Genetic disease Mammalia Primates Central nervous system disease Nervous system diseases Vertebrata
- Keyword (es)
- Agregación Benzoquinona derivado Corea Huntington Expresión genética Hombre Huntingtina Inducción Proteína choque térmico Riñón Mono Tratamiento Encéfalo patología Extrapiramidal síndrome Línea celular Enfermedad degenerativa Enfermedad hereditaria Mammalia Primates Sistema nervosio central patología Sistema nervioso patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1091726
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/hmg/10.12.1307 
https://dx.doi.org/10.1093/hmg/10.12.1307
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