Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide
- Author
- GANLEY, Brian1 ; CHOWDHURY, Goutam1 ; BHANSALI, Jennifer1 ; DANIELS, J. Scott1 ; GATES, Kent S1
[1] Departments of Chemistry and Biochemistry, University of Missouri-Columbia, Columbia, MO 65211, United States - Source
Bioorganic & medicinal chemistry. 2001, Vol 9, Num 9, pp 2395-2401 ; ref : 49 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Clivage Composé aromatique Composé bicyclique DNA Hypoxie Hétérocycle azote In vitro Mutagène Mécanisme action Nitrone Oxydoréduction Produit synthétique Quinoxaline dérivé Spécificité séquence Sélectivité Séquence nucléotide Quinoxaline 1,4-dioxyde Quinoxaline-2-carboxylique acide 1,4-dioxyde
- Keyword (en)
- Biological activity Antineoplastic agent Cleavage Aromatic compound Bicyclic compound DNA Hypoxia Nitrogen heterocycle In vitro Mutagen Mechanism of action Nitrone Oxidation reduction Synthetic product Quinoxaline derivatives Sequence specificity Selectivity Nucleotide sequence
- Keyword (es)
- Actividad biológica Anticanceroso Clivaje Compuesto aromático Compuesto bicíclico DNA Hipoxia Heterociclo nitrógeno In vitro Mutágeno Mecanismo acción Nitrona Oxidación reducción Producto sintético Quinoxalina derivado Espicificidad secuencia Selectividad Secuencia nucleótido
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology / 002B03N Chemical mutagenesis
- Discipline
- Pharmacological treatments Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1119591
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0968-0896(01)00163-8 
https://dx.doi.org/10.1016/S0968-0896(01)00163-8
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