Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action
- Author
- DE LOMBAERT, S1 ; BLANCHARD, L1 ; MARCOPOULOS, N1 ; SAVAGE, P1 ; CHOU, M1 ; TRAPANI, A. J1 ; JENG, A. Y1 ; STAMFORD, L. B1 ; TAN, J1 ; WALLACE, E. M1 ; SATOH, Y1 ; FITT, J1 ; HOYER, D1 ; SIMONSBERGEN, D1 ; MOLITERNI, J1
[1] Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, Summit, New Jersey 07901, United States - Source
Journal of medicinal chemistry (Print). 2000, Vol 43, Num 3, pp 488-504 ; ref : 44 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antihypertenseur Chimiothérapie Composé aromatique Composé non peptide Composé tricyclique Durée action Endothelin-converting enzyme 1 Homme Hypertension artérielle Hétérocycle azote Hétérocycle oxygène In vitro In vivo Inhibiteur enzyme Pathologie expérimentale Protéine recombinante Rat Relation structure activité Synthèse chimique Sélectivité Traitement Tétrazole dérivé Voie intraveineuse α-Aminoacide 3-Dibenzofurylalanine(N-[dihydroxyphosphorylméthyl]) CGS 34043 CGS 35066 Dibenzofurane dérivé Phosphonique acide([(2-dibenzofur-2-yl-1-tétrazol-5-yléthyl)amino]méthyl) Appareil circulatoire pathologie Enzyme Hydrolases Mammalia Metalloendopeptidases Peptidases Phosphore Composé organique Rodentia Vertebrata
- Keyword (en)
- Animal Antihypertensive agent Chemotherapy Aromatic compound Non peptide compound Tricyclic compound Duration of action Endothelin-converting enzyme 1 Human Hypertension Nitrogen heterocycle Oxygen heterocycle In vitro In vivo Enzyme inhibitor Experimental disease Recombinant protein Rat Structure activity relation Chemical synthesis Selectivity Treatment Tetrazole derivatives Intravenous administration α-Aminoacid Cardiovascular disease Enzyme Hydrolases Mammalia Metalloendopeptidases Peptidases Phosphorus Organic compounds Rodentia Vertebrata
- Keyword (es)
- Animal Antihipertensivo Quimioterapia Compuesto aromático Compuesto no péptido Compuesto tricíclico Duración acción Endothelin-converting enzyme 1 Hombre Hipertensión arterial Heterociclo nitrógeno Heterociclo oxígeno In vitro In vivo Inhibidor enzima Patología experimental Proteína recombinante Rata Relación estructura actividad Síntesis química Selectividad Tratamiento Tetrazol derivado Vía intravenosa α-Aminoácido Aparato circulatorio patología Enzima Hydrolases Mammalia Metalloendopeptidases Peptidases Fósforo Compuesto orgánico Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F05 Antihypertensive agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1278374
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm990507o 
https://dx.doi.org/10.1021/jm990507o
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