Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors
- Author
- LÜBBERS, T1 ; ANGEHRN, P1 ; GMÜNDER, H1 ; HERZIG, S1 ; KULHANEK, J1
[1] Department of Infectious Diseases, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland - Source
Bioorganic & medicinal chemistry letters (Print). 2000, Vol 10, Num 8, pp 821-826
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antibactérien Bactérie Gram positif Benzoïque acide dérivé Chlore Composé organique Composé bicyclique Coumarine dérivé DNA topoisomerase (ATP-hydrolysing) Fluor Composé organique Hétérocycle azote In vitro Inhibiteur enzyme Modèle moléculaire Modélisation Relation structure activité Résistance Réversibilité Synthèse chimique Pyrazolo[3,4-d]pyrimidine(4-amino-1-[3,5-dichlorophényl]-6-[4-hydroxy-2-oxo-1-benzopyran-7-yloxy]) Pyrazolo[3,4-d]pyrimidine(4-amino-6-[3-carboxyphénylthio]-3-éthyl-1-[3-fluorophényl]) Pyrazolopyrimidine Enzyme Isomerases
- Keyword (en)
- Antibacterial agent Gram positive bacteria Benzoic acid derivatives Chlorine Organic compounds Bicyclic compound Coumarine derivatives DNA topoisomerase (ATP-hydrolysing) Fluorine Organic compounds Nitrogen heterocycle In vitro Enzyme inhibitor Molecular model Modeling Structure activity relation Resistance Reversibility Chemical synthesis Enzyme Isomerases
- Keyword (es)
- Antibacteriano Bacteria Gram positiva Benzoico ácido derivado Cloro Compuesto orgánico Compuesto bicíclico DNA topoisomerase (ATP-hydrolysing) Fluor Compuesto orgánico Heterociclo nitrógeno In vitro Inhibidor enzima Modelo molecular Modelización Relación estructura actividad Resistencia Reversibilidad Síntesis química Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1342954
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0960-894X(00)00109-8 
https://dx.doi.org/10.1016/S0960-894X(00)00109-8
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