Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties
- Author
- MALAMAS, M. S1 ; SREDY, J1 ; TAYLOR, J. R1 ; MOXHAM, C1 ; KATZ, A1 ; WEIXIN XU1 ; MCDEVITT, R1 ; ADEBAYO, F. O1 ; SAWICKI, D. R1 ; SEESTALLER, L1 ; SULLIVAN, D1
[1] Wyeth-Ayerst Research, Inc., CN 8000, Princeton, New Jersey 08543-8000, United States - Source
Journal of medicinal chemistry (Print). 2000, Vol 43, Num 7, pp 1293-1310 ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Animal Benzofurane dérivé Biphényle dérivé Chimiothérapie Composé aromatique Composé bicyclique Diabète Ether Hypoglycémiant Hétérocycle oxygène Hétérocycle soufre In vitro In vivo Inhibiteur enzyme Protein-tyrosine-phosphatase Relation structure activité Souris Synthèse chimique Traitement Voie intrapéritonéale Voie orale Benzo[b]thiophène dérivé Benzothiophène Benzènepropionique acide(α-[4-(2-benzyl-1-benzofur-3-yl)-p-biphénylyl]) Enzyme Esterases Hydrolases Mammalia Phosphoric monoester hydrolases Rodentia Vertebrata
- Keyword (en)
- Carboxylic acid Animal Benzofuran derivatives Biphenyl derivatives Chemotherapy Aromatic compound Bicyclic compound Diabetes mellitus Ether Hypoglycemic agent Oxygen heterocycle Sulfur heterocycle In vitro In vivo Enzyme inhibitor Protein-tyrosine-phosphatase Structure activity relation Mouse Chemical synthesis Treatment Intraperitoneal administration Oral administration Enzyme Esterases Hydrolases Mammalia Phosphoric monoester hydrolases Rodentia Vertebrata
- Keyword (es)
- Acido carboxílico Animal Bifenilo derivado Quimioterapia Compuesto aromático Compuesto bicíclico Diabetes Eter Hipoglicemiante Heterociclo oxígeno Heterociclo azufre In vitro In vivo Inhibidor enzima Protein-tyrosine-phosphatase Relación estructura actividad Ratón Síntesis química Tratamiento Vía intraperitoneal Vía oral Enzima Esterases Hydrolases Mammalia Phosphoric monoester hydrolases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1344029
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm990560c 
https://dx.doi.org/10.1021/jm990560c
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