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Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts

Author
HEALD, Robert A1 ; MODI, Chetna1 ; COOKSON, Jenny C1 ; HUTCHINSON, Ian1 ; LAUGHTON, Charles A1 ; GOWAN, Sharon M2 ; KELLAND, Lloyd R2 ; STEVENS, Malcolm F. G1
[1] Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
[2] CRC Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
Source

Journal of medicinal chemistry (Print). 2002, Vol 45, Num 3, pp 590-597 ; ref : 34 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Anticancéreux Captation Cation organique Cellule tumorale Composé aromatique Composé hydrosoluble Composé tétracyclique Cytotoxicité Homme Hétérocycle azote Iminium composé In vitro Inhibiteur enzyme Lignée cellulaire Nucleotidyltransferases Relation structure activité Synthèse chimique NSC 714187 Quino[4,3,2-kl]acridinium(3,11-difluoro-6,8,13-triméthyl) sulfate(méthyl) Quinoacridine Quinoacridinium RHPS4 Enzyme Transferases
Keyword (en)
Antineoplastic agent Uptake Organic cation Tumor cell Aromatic compound Water soluble compound Tetracyclic compound Cytotoxicity Human Nitrogen heterocycle Iminium compounds In vitro Enzyme inhibitor Cell line Nucleotidyltransferases Structure activity relation Chemical synthesis Enzyme Transferases
Keyword (es)
Anticanceroso Captación Catión orgánico Célula tumoral Compuesto aromático Compuesto hidrosoluble Compuesto tetracíclico Citotoxicidad Hombre Heterociclo nitrógeno Iminio compuesto In vitro Inhibidor enzima Línea celular Nucleotidyltransferases Relación estructura actividad Síntesis química Enzima Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
13452379

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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