Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety
- Author
- ISHIOKA, Toshiyasu1 ; KUBO, Asako2 ; KOISO, Yukiko1 ; NAGASAWA, Kazuo1 ; ITAI, Akiko2 ; HASHIMOTO, Yuichi1
[1] Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan
[2] Institute of Medicinal Molecular Design, Key Molecular Inc., 4-24-5 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan - Source
Bioorganic & medicinal chemistry. 2002, Vol 10, Num 5, pp 1555-1566
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Androgène Antiandrogène Antihormone Chlore Composé organique Composé non stéroïde Fixation biologique Flutamide Homme Hétérocycle azote Hétérocycle oxygène azote In vitro Inhibition Isoxazole dérivé Lignée cellulaire Multiplication cellulaire Prostate Pyrrolidine dérivé Relation structure activité Récepteur androgène Récepteur hormonal Synthèse chimique Isoxazol-5-one(3-[4-chlorophényl]-4-[4-pyrrolidinobenzylidène]) Isoxazol-5-one(3-benzyl-4-[4-pyrrolidinobenzylidène]) Lignée LNCAP
- Keyword (en)
- Androgen Antiandrogen Antihormone Chlorine Organic compounds Non steroid compound Biological fixation Flutamide Human Nitrogen heterocycle Oxygen nitrogen heterocycle In vitro Inhibition Isoxazole derivatives Cell line Cell proliferation Prostate Pyrrolidine derivatives Structure activity relation Androgen receptor Hormonal receptor Chemical synthesis
- Keyword (es)
- Andrógeno Antiandrógeno Antihormona Cloro Compuesto orgánico Compuesto no esteroide Fijación biológica Flutamida Hombre Heterociclo nitrógeno Heterociclo oxígeno nitrógeno In vitro Inhibición Línea celular Multiplicación celular Prostata Relación estructura actividad Receptor andrógeno Receptor hormonal Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 13515640
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0968-0896(01)00421-7 
https://dx.doi.org/10.1016/S0968-0896(01)00421-7
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