CpG methylation is maintained in human cancer cells lacking DNMT1
- Author
- RHEE, I1 2 3 ; JAIR, K.-W2 ; CHIU YEN, R.-W2 ; LENGAUER, C2 ; HERMAN, J. G2 ; KINZLER, K. W2 3 ; VOGELSTEIN, B1 2 3 ; BAYLIN, S. B2 3 ; SCHUEBEL, K. E2
[1] The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, United States
[2] Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, United States
[3] Program in Human Genetics, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, United States - Source
Nature (London). 2000, Vol 404, Num 6781, pp 1003-1007 ; ref : 30 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Carcinogenèse Carcinome Cellule tumorale Côlon Déterminisme génétique Epigénétique Gène suppresseur tumeur Gène Génome Homme Lignée cellulaire établie Methyltransferases Méthylation Rectum Silence expression génique Spécificité réaction Séquence nucléotide Séquence riche GC Tumeur maligne Gène DNMMT1 Hyperméthylation Ilôt CpG Lignée HCT116 Lignée HT29 Appareil digestif pathologie Côlon pathologie Enzyme Intestin pathologie Rectum pathologie Transferases
- Keyword (en)
- Carcinogenesis Carcinoma Tumor cell Colon Genetic determinism Epigenetics Tumor suppressor gene Gene Genome Human Established cell line Methyltransferases Methylation Rectum Gene silencing Reaction specificity Nucleotide sequence GC rich sequence Malignant tumor Hypermethylation CpG island Digestive diseases Colonic disease Enzyme Intestinal disease Rectal disease Transferases
- Keyword (es)
- Carcinogénesis Carcinoma Célula tumoral Colón Determinismo genético Epigenética Gen supresor tumor Gen Genoma Hombre Línea celular establecida Methyltransferases Metilación Recto Silencio expresión genética Especificidad reacción Secuencia nucleótido Secuencia rica GC Tumor maligno Aparato digestivo patología Colón patología Enzima Intestino patología Recto patología Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04A General aspects
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1356490
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/35010000 
https://dx.doi.org/10.1038/35010000
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