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Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB1/CB2 receptors

Author
BROOKS, Jason W1 ; PRYCE, Gareth2 ; DI MARZO, Vincenzo3 ; BAKER, David2 ; BISOGNO, Tiziana3 ; JAGGAR, Sian I1 ; HANKEY, Deborah J. R2 ; BROWN, Peter4 ; BRIDGES, Daniel1 ; LEDENT, Catherine5 ; BIFULCO, Maurizio6 ; RICE, Andrew S. C1
[1] Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, United Kingdom
[2] Neuroinflammation Group, Institute of Neurology, University College London, London, United Kingdom
[3] Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34 Comprensorio Olivetti, Fabbricato 70, Arco Felice, 80078 Pozzuoli (Napoli), Italy
[4] Sobell Department of Neurophysiology, Institute of Neurology, University College London, London, United Kingdom
[5] IRIBHN, Universite libre de Bruxelles, Brussels, Belgium
[6] Endocannabinoid Research Group, Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo, 84084 Fisciano (SA), Italy
Source

European journal of pharmacology. 2002, Vol 439, Num 1-3, pp 83-92 ; ref : 40 ref

CODEN
EJPHAZ
ISSN
0014-2999
Scientific domain
Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Keyword (fr)
Activité biologique Agoniste Analgésique Animal Cannabinoïde Capsaïcine Douleur rebelle Etude comparative Hypertonie spastique Mécanisme action Rat Récepteur cannabinoïde Récepteur vanilloïde VR1 Site action Voie intraveineuse Arvanil Mammalia Rodentia Vertebrata
Keyword (en)
Biological activity Agonist Analgesic Animal Cannabinoid Capsaicin Intractable pain Comparative study Spasticity Mechanism of action Rat Cannabinoid receptor VR1 vanilloid receptor Site of action Intravenous administration Mammalia Rodentia Vertebrata
Keyword (es)
Actividad biológica Agonista Analgésico Animal Canabinoide Capsicina Dolor intratable Estudio comparativo Hipertonia espástica Mecanismo acción Rata Receptor canabinoide Receptor vaniloide VR1 Lugar acción Vía intravenosa Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B09 Ophthalmology / 002B09F Uvea diseases

Discipline
Ophthalmology Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
13628327

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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