The phosphatidylinositide 3'-kinase/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C
- Author
- TENZER, Angela1 2 ; ZINGG, Daniel1 2 ; ROCHA, Sonia1 ; HEMMINGS, Brian3 ; FABBRO, Doriano4 ; GLANZMANN, Christoph1 ; SCHUBIGER, P. August2 ; BODIS, Stephan1 ; PRUSCHY, Martin1
[1] Department of Radiation Oncology, University Hospital Zurich, 8091 Zurich, Switzerland
[2] Department of Applied Biosciences, ETH-Zurich, 8092 Zurich, Switzerland
[3] Friedrich Miescher Institute, 4058 Basel, Switzerland
[4] Novartis Pharma, Inc., Department of Oncology Research, 4002 Basel, Switzerland - Source
Cancer research (Baltimore). 2001, Vol 61, Num 22, pp 8203-8210 ; ref : 60 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 1-Phosphatidylinositol 3-kinase Activité biologique Anticancéreux Apoptose Cellule tumorale In vitro Inhibiteur enzyme Lignée cellulaire établie Mort cellulaire Multiplication cellulaire Mécanisme action Protein kinase C Radiosensibilisant Transduction signal PKC 412 Protein kinase AKT Enzyme Transferases
- Keyword (en)
- 1-Phosphatidylinositol 3-kinase Biological activity Antineoplastic agent Apoptosis Tumor cell In vitro Enzyme inhibitor Established cell line Cell death Cell proliferation Mechanism of action Protein kinase C Radiosensitizing agent Signal transduction Enzyme Transferases
- Keyword (es)
- 1-Phosphatidylinositol 3-kinase Actividad biológica Anticanceroso Apoptosis Célula tumoral In vitro Inhibidor enzima Línea celular establecida Muerte celular Multiplicación celular Mecanismo acción Protein kinase C Radiosensibilizante Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 13628782
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Install on your browser
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2001\";s:9:\"\u0000*\u0000volume\";s:2:\"61\";s:8:\"\u0000*\u0000issue\";s:2:\"22\";s:8:\"\u0000*\u0000spage\";s:4:\"8203\";s:8:\"\u0000*\u0000epage\";s:4:\"8210\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"TENZER\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Angela\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:13:\"ZINGG, Daniel\";i:1;s:12:\"ROCHA, Sonia\";i:2;s:15:\"HEMMINGS, Brian\";i:3;s:15:\"FABBRO, Doriano\";i:4;s:20:\"GLANZMANN, Christoph\";i:5;s:20:\"SCHUBIGER, P. August\";i:6;s:14:\"BODIS, Stephan\";i:7;s:15:\"PRUSCHY, Martin\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:0:\"\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2001\";s:9:\"\u0000*\u0000volume\";s:2:\"61\";s:8:\"\u0000*\u0000issue\";s:2:\"22\";s:8:\"\u0000*\u0000spage\";s:4:\"8203\";s:8:\"\u0000*\u0000epage\";s:4:\"8210\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"TENZER\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Angela\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:13:\"ZINGG, Daniel\";i:1;s:12:\"ROCHA, Sonia\";i:2;s:15:\"HEMMINGS, Brian\";i:3;s:15:\"FABBRO, Doriano\";i:4;s:20:\"GLANZMANN, Christoph\";i:5;s:20:\"SCHUBIGER, P. August\";i:6;s:14:\"BODIS, Stephan\";i:7;s:15:\"PRUSCHY, Martin\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:0:\"\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2001\";s:9:\"\u0000*\u0000volume\";s:2:\"61\";s:8:\"\u0000*\u0000issue\";s:2:\"22\";s:8:\"\u0000*\u0000spage\";s:4:\"8203\";s:8:\"\u0000*\u0000epage\";s:4:\"8210\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"TENZER\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Angela\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:13:\"ZINGG, Daniel\";i:1;s:12:\"ROCHA, Sonia\";i:2;s:15:\"HEMMINGS, Brian\";i:3;s:15:\"FABBRO, Doriano\";i:4;s:20:\"GLANZMANN, Christoph\";i:5;s:20:\"SCHUBIGER, P. August\";i:6;s:14:\"BODIS, Stephan\";i:7;s:15:\"PRUSCHY, Martin\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:0:\"\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2001\";s:9:\"\u0000*\u0000volume\";s:2:\"61\";s:8:\"\u0000*\u0000issue\";s:2:\"22\";s:8:\"\u0000*\u0000spage\";s:4:\"8203\";s:8:\"\u0000*\u0000epage\";s:4:\"8210\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"TENZER\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Angela\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:13:\"ZINGG, Daniel\";i:1;s:12:\"ROCHA, Sonia\";i:2;s:15:\"HEMMINGS, Brian\";i:3;s:15:\"FABBRO, Doriano\";i:4;s:20:\"GLANZMANN, Christoph\";i:5;s:20:\"SCHUBIGER, P. August\";i:6;s:14:\"BODIS, Stephan\";i:7;s:15:\"PRUSCHY, Martin\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:0:\"\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2001\";s:9:\"\u0000*\u0000volume\";s:2:\"61\";s:8:\"\u0000*\u0000issue\";s:2:\"22\";s:8:\"\u0000*\u0000spage\";s:4:\"8203\";s:8:\"\u0000*\u0000epage\";s:4:\"8210\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"TENZER\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Angela\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:13:\"ZINGG, Daniel\";i:1;s:12:\"ROCHA, Sonia\";i:2;s:15:\"HEMMINGS, Brian\";i:3;s:15:\"FABBRO, Doriano\";i:4;s:20:\"GLANZMANN, Christoph\";i:5;s:20:\"SCHUBIGER, P. August\";i:6;s:14:\"BODIS, Stephan\";i:7;s:15:\"PRUSCHY, Martin\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"The phosphatidylinositide 3'-kinase\/akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:0:\"\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
