Structure of an HIF-1α-pVHL colllplex: Hydroxyproline recognition in signaling
- Author
- MIN, Jung-Hyun1 ; HAIFENG YANG2 ; IVAN, Mlrcea2 ; GERTLER, Frank3 ; KAELIN, William G2 4 ; PAVLETICH, Nikola P1
[1] Cellular Biochemistry and Biophysics Program and Howard Hughes Medical Institute, Memorial SloanKettering Cancer Center, New York, NY 10021, United States
[2] Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, United States
[3] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
[4] Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, United States - Source
Science (Washington, D.C.). 2002, Vol 296, Num 5574, pp 1886-1889 ; ref : 29 ref
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Complexe Conformation Gène suppresseur tumeur Hydroxylation Liaison Oxygène Peptide Point chaud Tumorigénicité Ubiquitine Protéine HIF-1 Protéine pVHL Protéine
- Keyword (en)
- Complexes Conformation Tumor suppressor gene Hydroxylation Binding Oxygen Peptides Hot spot Tumorigenicity Ubiquitin Protein
- Keyword (es)
- Complejo Conformación Gen supresor tumor Hidroxilación Enlace Oxígeno Péptido Punto caliente Tumorigenicidad Ubiquitina Proteína
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H04 Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
- Discipline
- Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 13713314
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1073440 
https://dx.doi.org/10.1126/science.1073440
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