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Assessing the emetic potential of PDE4 inhibitors in rats

Author
ROBICHAUD, A1 ; SAVOIE, C1 ; STAMATIOU, P. B1 ; LACHANCE, N1 ; JOLICOEUR, P1 ; RASORI, R1 ; CHAN, C. C1
[1] Merck Frosst Centre for Therapeutic Research, P.O. Box 1005 Pointe-Claire, Dorval (Qc) H9R 4P8, Canada
Source

British journal of pharmacology. 2002, Vol 135, Num 1, pp 113-118 ; ref : 26 ref

CODEN
BJPCBM
ISSN
0007-1188
Scientific domain
Pharmacology drugs
Publisher
Nature Publishing, Basingstoke
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Anesthésique général Animal Association médicamenteuse Emétique Encéphale Inhibiteur enzyme Interaction médicamenteuse Mécanisme action Phosphoric diester hydrolases Rat Récepteur tachykinine NK1 Récepteur α2-adrénergique Système nerveux central Toxicité Voie souscutanée Vomissement Appareil digestif pathologie Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
Keyword (en)
General anesthetic Animal Drug combination Emetic Brain (vertebrata) Enzyme inhibitor Drug interaction Mechanism of action Phosphoric diester hydrolases Rat NK1 Tachykinin receptor α2-Adrenergic receptor Central nervous system Toxicity Subcutaneous administration Vomiting Digestive diseases Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
Keyword (es)
Anestésico general Animal Asociación medicamentosa Emético Encéfalo Inhibidor enzima Interacción medicamentosa Mecanismo acción Phosphoric diester hydrolases Rata Receptor taquikinina NK1 Receptor α2-adrenérgico Sistema nervioso central Toxicidad Vía subcutánea Vómito Aparato digestivo patología Enzima Esterases Hydrolases Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U04 Toxicity: digestive system

Discipline
Drugs toxicity and drug intoxications Toxicology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
13845328

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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