SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist
- Author
- ANTHES, John C1 ; CHAPMAN, Richard W1 ; RIZZO, Charles1 ; CRAWLEY, Yvette1 ; SHIH, Neng-Yang2 ; PIWINSKI, John2 ; REICHARD, Greg2 ; TING, Pauline2 ; CARRUTHERS, Nick3 ; CUSS, Francis M1 ; BILLAH, Motasim1 ; KREUTNER, William1 ; RICHARD, Christian1 ; EGAN, Robert W1 ; ECKEL, Stephen1 ; CORBOZ, Michel1 ; HEY, John A1 ; FERNANDEZ, Xiomara1 ; GREENFEDER, Scott1 ; MCLEOD, Robbie1 ; SEHRING, Susan1
[1] Department of Allergy, Schering-Plough Research Institute, K15-1-1600, 2015, Galloping Hill Road, Kenilworth, NJ 07033, United States
[2] Department of Chemistry, Schering-Plough Research Institute, Kenilworth, NJ 07033, United States
[3] R.W. Johnson Pharmaceutical Research Institute, San Diego, CA, United States - Source
European journal of pharmacology. 2002, Vol 450, Num 2, pp 191-202 ; ref : 1 p.1/4
- CODEN
- EJPHAZ
- ISSN
- 0014-2999
- Scientific domain
- Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste Antiinflammatoire Appareil circulatoire Appareil respiratoire Artère pulmonaire Broche Chien Cobaye Fixation biologique Homme In vitro In vivo Lignée CHO Lignée cellulaire établie Mécanisme action Protéine recombinante Relâchement musculaire Récepteur tachykinine NK1 Récepteur tachykinine NK2 Récepteur tachykinine NK3 Vaisseau sanguin Vasoconstricteur Voie orale SCH 206272 Carnivora Fissipedia Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antagonist Antiinflammatory agent Circulatory system Respiratory system Pulmonary artery Pin Dog Guinea pig Biological fixation Human In vitro In vivo CHO cell line Established cell line Mechanism of action Recombinant protein Muscular relaxation NK1 Tachykinin receptor NK2 Tachykinin receptor NK3 Tachykinin receptor Blood vessel Vasoconstrictor agent Oral administration Carnivora Fissipedia Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antagonista Antiinflamatorio Aparato circulatorio Aparato respiratorio Arteria pulmonar Alambre Perro Cobayo Fijación biológica Hombre In vitro In vivo Célula CHO Línea celular establecida Mecanismo acción Proteína recombinante Relajación muscular Receptor taquikinina NK1 Receptor taquikinina NK2 Receptor taquikinina NK3 Vaso sanguíneo Vasoconstrictor Vía oral Carnivora Fissipedia Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 13859068
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0014-2999(02)02124-6 
https://dx.doi.org/10.1016/S0014-2999(02)02124-6
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arXiv access
