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Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3

Author
EMANUELE, Sonia1 ; CALVARUSO, Giuseppe1 ; LAURICELLA, Marianna1 ; GIULIANO, Michela1 ; BELLAVIA, Giuseppe1 ; D'ANNEO, Antonella1 ; VENTO, Renza1 ; TESORIERE, Giovanni1
[1] Department of Cell and Developmental Biology, Section of Biochemistry, University of Palermo, Policlinico, Palermo, Italy
Source

International journal of oncology. 2002, Vol 21, Num 4, pp 857-865 ; ref : 46 ref

ISSN
1019-6439
Scientific domain
Medical oncology
Publisher
Editorial Academy of the International Journal of Oncology, Athens
Publication country
Greece
Document type
Article
Language
English
Keyword (fr)
Activité biologique Aldéhyde Anticancéreux Apoptose Caspase Gène onc cellulaire Homme Homologie Hydrogénoperoxyde Hépatoblastome In vitro Inhibiteur enzyme Lignée cellulaire établie Mort cellulaire Multicatalytic endopeptidase complex Peptide Protooncogène Stress oxydatif Caspase 3 Gène bcl XS Gène bcl2 Lignée HepG2 MG132 Appareil digestif pathologie Cysteine endopeptidases Enzyme Foie pathologie Génétique Hydrolases Peptidases Tumeur maligne
Keyword (en)
Biological activity Aldehyde Antineoplastic agent Apoptosis Caspase C-Onc gene Human Homology Hydrogenperoxides Hepatoblastoma In vitro Enzyme inhibitor Established cell line Cell death Multicatalytic endopeptidase complex Peptides Protooncogene Oxidative stress Digestive diseases Cysteine endopeptidases Enzyme Hepatic disease Genetics Hydrolases Peptidases Malignant tumor
Keyword (es)
Actividad biológica Aldehído Anticanceroso Apoptosis Caspase Gen onc celular Hombre Homología Hidrogenoperóxido Hepatoblastoma In vitro Inhibidor enzima Línea celular establecida Muerte celular Multicatalytic endopeptidase complex Péptido Protooncogen Estrés oxidativo Aparato digestivo patología Cysteine endopeptidases Enzima Hígado patología Genética Hydrolases Peptidases Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
13887371

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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