Design of noncovalent inhibitors of human cathepsin L. from the 96-residue proregion to optimized tripeptides
- Author
- CHOWDHURY, Shafinaz F1 ; SIVARAMAN, J1 ; SULEA, Traian1 ; PURISIMA, Enrico O1 ; JING WANG1 ; DEVANATHAN, Gopal1 ; LACHANCE, Paule1 ; QI, Hongtao1 ; MENARD, Robert1 ; LEFEBVRE, Jean1 ; KONISHI, Yasuo1 ; CYGLER, Miroslaw1
[1] Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada - Source
Journal of medicinal chemistry (Print). 2002, Vol 45, Num 24, pp 5321-5329, 9 p ; ref : 39 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cathepsin L Complexe enzyme inhibiteur Diffraction RX Homme In vitro Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Peptide soufre Peptide Phase solide Prédiction Relation structure activité Structure cristalline Synthèse chimique Synthèse peptidique Tripeptide Biphényle-4-acétique acide dér Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (en)
- Cathepsin L Inhibitor enzyme complex X ray diffraction Human In vitro Enzyme inhibitor Binding mode Molecular model Modeling Sulfur peptide Peptides Solid phase Prediction Structure activity relation Crystalline structure Chemical synthesis Peptide synthesis Tripeptide Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (es)
- Cathepsin L Complejo enzima inhibidor Difracción RX Hombre In vitro Inhibidor enzima Modo de enlace Modelo molecular Modelización Péptido azufre Péptido Fase sólida Predicción Relación estructura actividad Estructura cristalina Síntesis química Síntesis peptídica Tripéptido Cysteine endopeptidases Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14039022
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm020238t 
https://dx.doi.org/10.1021/jm020238t
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