The tyrosine kinase inhibitor ZD1839 (iressa) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
- Author
- MOASSER, Mark M1 ; BASSO, Andrea2 ; AVERBUCH, Steven D3 4 ; RNSEN, Neal1 5
[1] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, United States
[2] Program in Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States
[3] AstraZeneca Pharmaceuticals, Wilmington, Delaware 19850, United States
[4] Macclesfield, Cheshire SK10 4TG, United Kingdom
[5] Program in Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, United States - Source
Cancer research (Baltimore). 2001, Vol 61, Num 19, pp 7184-7188 ; ref : 20 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Cellule tumorale Etude comparative Expression génique Homme In vitro Inhibiteur enzyme Lignée cellulaire établie Mécanisme action Produit gène Protein-tyrosine kinase Récepteur facteur croissance Sensibilité résistance Surexpression génique Transduction signal Tumeur maligne Gène erbB2 ZD 1839 Enzyme Transferases
- Keyword (en)
- Biological activity Antineoplastic agent Tumor cell Comparative study Gene expression Human In vitro Enzyme inhibitor Established cell line Mechanism of action Gene product Protein-tyrosine kinase Growth factor receptor Sensitivity resistance Gene overexpression Signal transduction Malignant tumor Enzyme Transferases
- Keyword (es)
- Actividad biológica Anticanceroso Célula tumoral Estudio comparativo Expresión genética Hombre In vitro Inhibidor enzima Línea celular establecida Mecanismo acción Producto gene Protein-tyrosine kinase Receptor factor crecimiento Sensibilidad resistencia Sobreexpressión genética Transducción señal Tumor maligno Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14086782
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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