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Stereochemistry as a major determinant of the anti-HIV activity of chiral naphthyl thiourea compounds

Author
VENKATACHALAM, T. K1 2 ; MAO, C1 3 ; UCKUN, F. M1 4
[1] Drug Discovery Program, Parker Hughes Institute, St Paul, Minn., United States
[2] Department of Chemistry, Parker Hughes Institute, St Paul, Minn., United States
[3] Department of Structural Biology, Parker Hughes Institute, St Paul, Minn., United States
[4] Department of Virology, Parker Hughes Institute, St Paul, Minn., United States
Source

Antiviral chemistry & chemotherapy. 2001, Vol 12, Num 4, pp 213-221 ; ref : 22 ref

ISSN
0956-3202
Scientific domain
Microbiology, infectious diseases; Pharmacology drugs; Virology
Publisher
International Medical Press, London
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Activité biologique Antiviral Composé non nucléoside In vitro Inhibiteur enzyme RNA-directed DNA polymerase Relation structure activité Stéréochimie Synthèse chimique Thiourée Virus immunodéficience humaine Enzyme Lentivirus Nucleotidyltransferases Retroviridae Transferases Virus
Keyword (en)
Biological activity Antiviral Non nucleoside compound In vitro Enzyme inhibitor RNA-directed DNA polymerase Structure activity relation Stereochemistry Chemical synthesis Thiourea Human immunodeficiency virus Enzyme Lentivirus Nucleotidyltransferases Retroviridae Transferases Virus
Keyword (es)
Actividad biológica Antiviral Compuesto no nucleósido In vitro Inhibidor enzima RNA-directed DNA polymerase Relación estructura actividad Estereoquímica Síntesis química Tiourea Human immunodeficiency virus Enzima Lentivirus Nucleotidyltransferases Retroviridae Transferases Virus
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14094901

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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