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Assays to predict the genotoxicity of the chromosomal mutagen etoposide - focussing on the best assay

Author
TURNER, S. D1 ; WIJNHOVEN, S. W. P2 ; TINWELL, H3 ; LASHFORD, L. S1 4 ; RAFFERTY, J. A1 ; ASHBY, J3 ; VRIELING, H2 ; FAIRBAIRN, L. J1
[1] Gene Therapy Group, Christie Hospital (NHS) Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
[2] Department of Radiation Genetics and Chemical Mutagenesis-MGC, Leiden University Medical Centre, P.O. Box 9503, 2300 RA Leiden, Netherlands
[3] Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
[4] Paterson Institute for Cancer Research and Academic Department of Paediatric Oncology, Christie Hospital (NHS) Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
Source

Mutation research. Genetic toxicology and environmental mutagenesis. 2001, Vol 493, Num 1-2, pp 139-147 ; ref : 40 ref

ISSN
1383-5718
Scientific domain
Environment; Genetics; Toxicology
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Keyword (fr)
Aberration chromosomique Adenine phosphoribosyltransferase Etoposide Gène In vivo Lésion Modèle animal Mutation Souris Test comète Test micronucléus Test mutagénicité Toxicité Anticancéreux Enzyme Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
Keyword (en)
Chromosomal aberration Adenine phosphoribosyltransferase Etoposide Gene In vivo Lesion Animal model Mutation Mouse Comet assay Micronucleus test Mutagenicity testing Toxicity Antineoplastic agent Enzyme Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
Keyword (es)
Aberración cromosómica Adenine phosphoribosyltransferase Etopósido Gen In vivo Lesión Modelo animal Mutación Ratón Cometa prueba Prueba micronúcleo Prueba mutagenicidad Toxicidad Anticanceroso Enzima Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U10 Miscellaneous (drug allergy, mutagens, teratogens...)

Discipline
Drugs toxicity and drug intoxications Toxicology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14099383

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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