Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype
- Author
- KRAMER, Debora L1 ; CHANG, Bey-Dih2 ; YING CHEN1 ; DIEGELMAN, Paula1 ; AIM, Kersti1 ; BLACK, Adrian R1 ; RONINSON, Igor B2 ; PORTER, Carl W1
[1] Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, United States
[2] Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607-7170, United States - Source
Cancer research (Baltimore). 2001, Vol 61, Num 21, pp 7754-7762 ; ref : 53 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Adenosylmethionine decarboxylase Anticancéreux Cellule tumorale Cycle cellulaire Déplétion Eflornithine Expression génique Homme In vitro Inhibiteur enzyme Lignée cellulaire établie Multiplication cellulaire Mélanome malin Ornithine decarboxylase Phase G1 Phosphorylation Phénotype Polyamine Protéine rétinoblastome Sénescence Transduction signal Gène p21 MDL 73811 Carbon-carbon lyases Carboxy-lyases Enzyme Lyases Tumeur maligne
- Keyword (en)
- Biological activity Adenosylmethionine decarboxylase Antineoplastic agent Tumor cell Cell cycle Depletion Eflornithine Gene expression Human In vitro Enzyme inhibitor Established cell line Cell proliferation Malignant melanoma Ornithine decarboxylase G1 Phase Phosphorylation Phenotype Polyamine Retinoblastoma protein Senescence Signal transduction Carbon-carbon lyases Carboxy-lyases Enzyme Lyases Malignant tumor
- Keyword (es)
- Actividad biológica Adenosylmethionine decarboxylase Anticanceroso Célula tumoral Ciclo celular Depleción Eflornitina Expresión genética Hombre In vitro Inhibidor enzima Línea celular establecida Multiplicación celular Melanoma maligno Ornithine decarboxylase Fase G1 Fosforilación Fenotipo Poliamina Proteína retinoblastoma Senescencia Transducción señal Carbon-carbon lyases Carboxy-lyases Enzima Lyases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14124387
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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