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A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia

Author
COOPER, Brenda W1 ; DONAHER, Erin1 ; GERSON, Stanton L1 ; LAZARUS, Hillard M1 ; GREEN, Sylvan B1 ; GOSKY, David M1 ; ROSENTHAL, Nancy S1 ; BERGER, Sosamma J1 ; XIAOLIN LI1 ; INGALLS, Stephen T1 ; HOPPEL, Charles L1
[1] Departments of Medicine, Biostatistics and Epidemiology, Pharmacology, and Pathology of University Hospitals of Cleveland, Ireland Cancer Center, Case Western Reserve University, Louis Stokes Veterans Affairs Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, United States
Source

Leukemia research. 2003, Vol 27, Num 1, pp 35-44, 10 p ; ref : 56 ref

CODEN
LEREDD
ISSN
0145-2126
Scientific domain
Medical oncology; Hematology
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Acute leukemia Sequential topoisomerase I and II inhibitors
Keyword (fr)
Activité biologique Aigu Antimitotique Association médicamenteuse Chimiothérapie DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Essai clinique phase I Etoposide Homme Inhibiteur enzyme Leucémie lymphoblastique Leucémie myéloblastique Pharmacocinétique Podophyllotoxine dérivé Rythme administration Récidive Résistance traitement Séquentiel Topotécane Traitement Voie intraveineuse Pyrano indolizino quinoléine dérivé Enzyme Hémopathie maligne Isomerases Lymphoprolifératif syndrome
Keyword (en)
Biological activity Acute Antimitotic Drug combination Chemotherapy DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Phase I trial Etoposide Human Enzyme inhibitor Acute lymphocytic leukemia Acute myelocytic leukemia Pharmacokinetics Podophyllotoxine derivatives Administration schedule Relapse Treatment resistance Sequential Topotecan Treatment Intravenous administration Enzyme Malignant hemopathy Isomerases Lymphoproliferative syndrome
Keyword (es)
Actividad biológica Agudo Antimitótico Asociación medicamentosa Quimioterapia DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Ensayo clínico fase I Etopósido Hombre Inhibidor enzima Leucemia linfoblástica Leucemia mieloblástica Farmacocinética Podofilotoxina derivado Ritmo administración Recaida Resistencia tratamiento Secuencial Topotecán Tratamiento Vía intravenosa Enzima Hemopatía maligna Isomerases Linfoproliferativo síndrome
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14407390

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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