A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists
- Author
- TUCCI, Fabio C1 ; ZHU, Yun-Fei1 ; ZHIQIANG GUO1 ; GROSS, Timothy D1 ; CONNORS, Patrick J1 ; STRUTHERS, R. Scott1 ; REINHART, Greg J1 ; XIAOCHUAN WANG1 ; SAUNDERS, John1 ; CHEN CHEN1
[1] Neurocrine Biosciences, Inc., 10555 Science Center Drive, San Diego, CA 92121, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Amine tertiaire Composé benzénique Composé bicyclique Composé non peptide Cétoester Facteur libération hormonale Fixation biologique Gonadotrophine RH Hormone peptide Hétérocycle azote angulaire In vitro Lactame Modèle moléculaire Modélisation Relation structure activité Récepteur peptidergique Synthèse chimique Lignée HEK293 Pyrrolo[1,2-a]pyrimidine-3-carboxylique acide(1,4-dihydro-8-fluoro-1-[2-fluorobenzyl]-7-[4-isobutoxyphényl]-6-[(2-[2-pyridyl]éthyl méthyl amino)méthyl]-4-oxo) ester éthyle Pyrrolopyrimidine Fluor Composé organique
- Keyword (en)
- Tertiary amine Benzenic compound Bicyclic compound Non peptide compound Ketoester Hormone releasing factor Biological fixation Gonadotropin RH Peptide hormone Angular nitrogen heterocycle In vitro Lactam Molecular model Modeling Structure activity relation Peptidergic receptor Chemical synthesis Fluorine Organic compounds
- Keyword (es)
- Amina terciaria Compuesto bencénico Compuesto bicíclico Compuesto no péptido Cetoester Factor liberación hormonal Fijación biológica Gonadotropina RH Hormona péptido Heterociclo nitrógeno angular In vitro Lactamo Modelo molecular Modelización Relación estructura actividad Receptor peptidérgico Síntesis química Fluor Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14493325
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0960-894X(02)00745-X 
https://dx.doi.org/10.1016/S0960-894X(02)00745-X
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