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A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists

Author
TUCCI, Fabio C1 ; ZHU, Yun-Fei1 ; ZHIQIANG GUO1 ; GROSS, Timothy D1 ; CONNORS, Patrick J1 ; STRUTHERS, R. Scott1 ; REINHART, Greg J1 ; XIAOCHUAN WANG1 ; SAUNDERS, John1 ; CHEN CHEN1
[1] Neurocrine Biosciences, Inc., 10555 Science Center Drive, San Diego, CA 92121, United States
Source

Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, 5 p

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Amine tertiaire Composé benzénique Composé bicyclique Composé non peptide Cétoester Facteur libération hormonale Fixation biologique Gonadotrophine RH Hormone peptide Hétérocycle azote angulaire In vitro Lactame Modèle moléculaire Modélisation Relation structure activité Récepteur peptidergique Synthèse chimique Lignée HEK293 Pyrrolo[1,2-a]pyrimidine-3-carboxylique acide(1,4-dihydro-8-fluoro-1-[2-fluorobenzyl]-7-[4-isobutoxyphényl]-6-[(2-[2-pyridyl]éthyl méthyl amino)méthyl]-4-oxo) ester éthyle Pyrrolopyrimidine Fluor Composé organique
Keyword (en)
Tertiary amine Benzenic compound Bicyclic compound Non peptide compound Ketoester Hormone releasing factor Biological fixation Gonadotropin RH Peptide hormone Angular nitrogen heterocycle In vitro Lactam Molecular model Modeling Structure activity relation Peptidergic receptor Chemical synthesis Fluorine Organic compounds
Keyword (es)
Amina terciaria Compuesto bencénico Compuesto bicíclico Compuesto no péptido Cetoester Factor liberación hormonal Fijación biológica Gonadotropina RH Hormona péptido Heterociclo nitrógeno angular In vitro Lactamo Modelo molecular Modelización Relación estructura actividad Receptor peptidérgico Síntesis química Fluor Compuesto orgánico
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14493325

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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