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A structure activity relationship study on position-2 of the Gαs C-terminal peptide able to inhibit Gs activation by A2A adenosine receptor

Author
GRIECO, Paolo1 ; ALBRIZIO, Stefania1 ; D'URI, Anna Maria2 ; GIUSTI, Laura3 ; MAZZONI, Maria R3 ; NOVELLINO, Ettore1 ; ROVERO, Paolo2
[1] Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli 'Federico II', Napoli, Italy
[2] Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 11C, 84084 Salerno, Italy
[3] Dipartimento di Psichiatira, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, Italy
Source

European journal of medicinal chemistry. 2003, Vol 38, Num 1, pp 13-18, 6 p ; ref : 24 ref

CODEN
EJMCA5
ISSN
0223-5234
Scientific domain
Organic chemistry; Pharmacology drugs
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
A2A receptors G protein Molecular dynamics Synthetic peptides
Keyword (fr)
Adenylate cyclase In vitro Inhibiteur enzyme Inhibition Modèle moléculaire Modélisation Méthode champ force Peptide Phase solide Polypeptide Protéine G Relation structure activité Récepteur adénosinique A2A Synthèse chimique Synthèse peptidique Séquence C terminale Transduction signal Undécapeptide Enzyme Lyases Phosphorus-oxygen lyases
Keyword (en)
Adenylate cyclase In vitro Enzyme inhibitor Inhibition Molecular model Modeling Force field method Peptides Solid phase Polypeptide G protein Structure activity relation A2A adenosine receptor Chemical synthesis Peptide synthesis C terminal-Sequence Signal transduction Enzyme Lyases Phosphorus-oxygen lyases
Keyword (es)
Adenylate cyclase In vitro Inhibidor enzima Inhibición Modelo molecular Modelización Método campo fuerza Péptido Fase sólida Polipéptido Proteína G Relación estructura actividad Receptor adenosínico A2A Síntesis química Síntesis peptídica Secuencia C terminal Transducción señal Enzima Lyases Phosphorus-oxygen lyases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14560519

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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