CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors
- Author
- WILCOX, R. E1 ; HUANG, W.-H1 ; BRUSNIAK, M.-Y. K2 ; WILCOX, D. M1 ; PEARLMAN, R. S2 ; TEETER, M. M3 ; DURAND, C. J3 4 ; WIENS, B. L5 ; NEVER, K. A5
[1] Molecular Pharmacology Laboratory, College of Pharmacy, and Institute for Neuroscience, University of Texas, Austin, Texas 78712, United States
[2] Laboratory for Molecular Graphics and Theoretical Modeling, College of Pharmacy, and Institute for Neuroscience, University of Texas, Austin, Texas 78712, United States
[3] Laboratory of Protein Modeling, Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02167, United States
[4] Psychiatry Service, Department of Veterans Affairs Medical Center, Bedford, Massachusetts 01730, United States
[5] Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201, United States - Source
Journal of medicinal chemistry (Print). 2000, Vol 43, Num 16, pp 3005-3019 ; ref : 34 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Agoniste Antiparkinsonien Bromocriptine Ergot dérivé Homologie Modèle moléculaire Modélisation Mutation Pergolide Prédiction Relation structure activité Récepteur dopaminergique D2 Stimulant dopaminergique Méthode CoMFA
- Keyword (en)
- Affinity Agonist Antiparkinson agent Bromocriptine Ergot derivatives Homology Molecular model Modeling Mutation Pergolide Prediction Structure activity relation D2 Dopamine receptor Dopamine agonist Comparative molecular field analysis method
- Keyword (es)
- Afinidad Agonista Antiparkinsoniano Bromocriptina Ergot derivado Homología Modelo molecular Modelización Mutación Pergolida Predicción Relación estructura actividad Receptor dopaminérgico D2 Estimulante dopaminérgico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1458435
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm990526y 
https://dx.doi.org/10.1021/jm990526y
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