Loss of integrin αvβ60-mediated TGF-β activation causes Mmp12-dependent emphysema

Author

MORRIS, David G^{1 2} ; XIAOZHU HUANG¹ ; KAMINSKI, Naftali³ ; YANLI WANG¹ ; SHAPIRO, Steven D⁴ ; DOLGANOV, Gregory² ; GLICK, Adam⁵ ; SHEPPARD, Dean^{1 2}
[1] Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, United States
[2] Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, California 94143, United States
[3] Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States
[4] Department of Medicine, Section of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States
[5] Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892, United States

Source

Nature (London). 2003, Vol 422, Num 6928, pp 169-173, 5 p ; ref : 27 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Animal Déficit Emphysème Facteur croissance transformant β Intégrine Metalloendopeptidases Modèle animal Souris Appareil respiratoire pathologie Bronche pathologie Bronchopneumopathie obstructive Enzyme Hydrolases Mammalia Peptidases Poumon pathologie Rodentia Vertebrata

Keyword (en)

Animal Deficiency Emphysema Transforming growth factor β Integrin Metalloendopeptidases Animal model Mouse Respiratory disease Bronchus disease Obstructive pulmonary disease Enzyme Hydrolases Mammalia Peptidases Lung disease Rodentia Vertebrata

Keyword (es)

Animal Déficiencia Enfisema Factor crecimiento transformante β Integrina Metalloendopeptidases Modelo animal Ratón Aparato respiratorio patología Bronquio patología Broncopneumopatía obstructiva Enzima Hydrolases Mammalia Peptidases Pulmón patología Rodentia Vertebrata

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11D Respiratory system : syndromes and miscellaneous diseases

Discipline

Pulmonology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

14661094

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS