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A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung

Author
CSANADY, Gy. A1 2 ; KESSLER, W1 2 ; HOFFMANN, H. D3 ; FILSER, J. G1 2
[1] GSF-lnstitute of Toxicology, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany
[2] Technische Universität München, München, Germany
[3] Prev. BASF AG, Department of Product Safety, Ludwigshafen, Germany
Source

Toxicology letters. 2003, Vol 138, Num 1-2, pp 75-102, 28 p ; ref : 3 p.1/4

CODEN
TOLED5
ISSN
0378-4274
Scientific domain
Toxicology
Publisher
Elsevier Science, Amsterdam / Elsevier Science, Shannon
Publication country
Ireland
Document type
Article
Language
English
Author keyword
DNA adducts GSH depletion Hemoglobin adducts Humans Physiological toxicokinetic model Pulmonary metabolism Rodents Styrene-7, 8-oxide Styrene
Keyword (fr)
Animal Carcinogène Cinétique Distribution Epoxyde Evaluation risque Homme Hydrocarbure Inhalation Modèle PBPK Modélisation Métabolisme Métabolite Poumon Rat Souris Styrène Tissu Toxicité Toxicocinétique Voie orale Oxirane(phényl) Appareil respiratoire pathologie Mammalia Rodentia Vertebrata
Keyword (en)
Animal Carcinogen Kinetics Distribution Epoxide Risk assessment Human Hydrocarbon Inhalation Physiologically based pharmacokinetic model Modeling Metabolism Metabolite Lung Rat Mouse Styrene Tissue Toxicity Toxicokinetics Oral administration Respiratory disease Mammalia Rodentia Vertebrata
Keyword (es)
Animal Carcinógeno Cinética Distribución Epóxido Hombre Hidrocarburo Inhalación PBPK modelo Modelización Metabolismo Metabolito Pulmón Rata Ratón Estireno Tejido Toxicidad Toxicocinética Vía oral Aparato respiratorio patología Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04E Carcinogenesis, carcinogens and anticarcinogens / 002B04E02 Chemical agents

Discipline
Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14680817

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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