A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung
- Author
- CSANADY, Gy. A1 2 ; KESSLER, W1 2 ; HOFFMANN, H. D3 ; FILSER, J. G1 2
[1] GSF-lnstitute of Toxicology, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany
[2] Technische Universität München, München, Germany
[3] Prev. BASF AG, Department of Product Safety, Ludwigshafen, Germany - Source
Toxicology letters. 2003, Vol 138, Num 1-2, pp 75-102, 28 p ; ref : 3 p.1/4
- CODEN
- TOLED5
- ISSN
- 0378-4274
- Scientific domain
- Toxicology
- Publisher
- Elsevier Science, Amsterdam
/
Elsevier Science, Shannon
- Publication country
- Ireland
- Document type
- Article
- Language
- English
- Author keyword
- DNA adducts GSH depletion Hemoglobin adducts Humans Physiological toxicokinetic model Pulmonary metabolism Rodents Styrene-7, 8-oxide Styrene
- Keyword (fr)
- Animal Carcinogène Cinétique Distribution Epoxyde Evaluation risque Homme Hydrocarbure Inhalation Modèle PBPK Modélisation Métabolisme Métabolite Poumon Rat Souris Styrène Tissu Toxicité Toxicocinétique Voie orale Oxirane(phényl) Appareil respiratoire pathologie Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Carcinogen Kinetics Distribution Epoxide Risk assessment Human Hydrocarbon Inhalation Physiologically based pharmacokinetic model Modeling Metabolism Metabolite Lung Rat Mouse Styrene Tissue Toxicity Toxicokinetics Oral administration Respiratory disease Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Carcinógeno Cinética Distribución Epóxido Hombre Hidrocarburo Inhalación PBPK modelo Modelización Metabolismo Metabolito Pulmón Rata Ratón Estireno Tejido Toxicidad Toxicocinética Vía oral Aparato respiratorio patología Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04E Carcinogenesis, carcinogens and anticarcinogens / 002B04E02 Chemical agents
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14680817
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0378-4274(02)00409-5 
https://dx.doi.org/10.1016/S0378-4274(02)00409-5
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