HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
- Author
- LOGANZO, Frank1 ; DISCAFANI, Carolyn M1 ; SINGANALLORE, Thiruvikraman2 ; KHAFIZOVA, Gulnaz2 ; PORUCHYNSKY, Marianne S3 ; FOJO, Tito3 ; NIEMAN, James A4 ; AYRAL-KALOUSTIAN, Semiramis2 ; ZASK, Arie2 ; ANDERSEN, Raymond J4 ; GREENBERGER, Lee M1 ; ANNABLE, Tami1 ; BEYER, Carl1 ; MUSTO, Sylvia1 ; HARI, Malathi1 ; XINGZHI TAN1 ; HARDY, Carolyn1 ; HERNANDEZ, Richard1 ; BAXTER, Michelle1
[1] Oncology Research, Wyeth Research, Pearl River, New York 10965, United States
[2] Chemical Sciences, Wyeth Research, Pearl River, New York 10965, United States
[3] The National Cancer Institute Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States
[4] Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada - Source
Cancer research (Baltimore). 2003, Vol 63, Num 8, pp 1838-1845, 8 p ; ref : 32 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Analogue Animal Anticancéreux Antimitotique Cellule tumorale Chimiothérapie Glycoprotéine P Homme In vitro In vivo Lignée cellulaire établie Mécanisme action Résistance multiple Souris Traitement Tripeptide Tumeur maligne Voie intraveineuse HTI 286 Hémiasterline Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Analog Animal Antineoplastic agent Antimitotic Tumor cell Chemotherapy P Glycoprotein Human In vitro In vivo Established cell line Mechanism of action Multiple resistance Mouse Treatment Tripeptide Malignant tumor Intravenous administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Análogo Animal Anticanceroso Antimitótico Célula tumoral Quimioterapia Glicoproteína P Hombre In vitro In vivo Línea celular establecida Mecanismo acción Resistencia múltiple Ratón Tratamiento Tripéptido Tumor maligno Vía intravenosa Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14729244
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Install on your browser
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"63\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:4:\"1838\";s:8:\"\u0000*\u0000epage\";s:4:\"1845\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"LOGANZO\";s:10:\"\u0000*\u0000aufirst\";s:5:\"Frank\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:18:{i:0;s:20:\"DISCAFANI, Carolyn M\";i:1;s:27:\"SINGANALLORE, Thiruvikraman\";i:2;s:17:\"KHAFIZOVA, Gulnaz\";i:3;s:23:\"PORUCHYNSKY, Marianne S\";i:4;s:10:\"FOJO, Tito\";i:5;s:15:\"NIEMAN, James A\";i:6;s:27:\"AYRAL-KALOUSTIAN, Semiramis\";i:7;s:10:\"ZASK, Arie\";i:8;s:19:\"ANDERSEN, Raymond J\";i:9;s:18:\"GREENBERGER, Lee M\";i:10;s:13:\"ANNABLE, Tami\";i:11;s:11:\"BEYER, Carl\";i:12;s:13:\"MUSTO, Sylvia\";i:13;s:13:\"HARI, Malathi\";i:14;s:11:\"XINGZHI TAN\";i:15;s:14:\"HARDY, Carolyn\";i:16;s:18:\"HERNANDEZ, Richard\";i:17;s:16:\"BAXTER, Michelle\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"63\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:4:\"1838\";s:8:\"\u0000*\u0000epage\";s:4:\"1845\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"LOGANZO\";s:10:\"\u0000*\u0000aufirst\";s:5:\"Frank\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:18:{i:0;s:20:\"DISCAFANI, Carolyn M\";i:1;s:27:\"SINGANALLORE, Thiruvikraman\";i:2;s:17:\"KHAFIZOVA, Gulnaz\";i:3;s:23:\"PORUCHYNSKY, Marianne S\";i:4;s:10:\"FOJO, Tito\";i:5;s:15:\"NIEMAN, James A\";i:6;s:27:\"AYRAL-KALOUSTIAN, Semiramis\";i:7;s:10:\"ZASK, Arie\";i:8;s:19:\"ANDERSEN, Raymond J\";i:9;s:18:\"GREENBERGER, Lee M\";i:10;s:13:\"ANNABLE, Tami\";i:11;s:11:\"BEYER, Carl\";i:12;s:13:\"MUSTO, Sylvia\";i:13;s:13:\"HARI, Malathi\";i:14;s:11:\"XINGZHI TAN\";i:15;s:14:\"HARDY, Carolyn\";i:16;s:18:\"HERNANDEZ, Richard\";i:17;s:16:\"BAXTER, Michelle\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"63\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:4:\"1838\";s:8:\"\u0000*\u0000epage\";s:4:\"1845\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"LOGANZO\";s:10:\"\u0000*\u0000aufirst\";s:5:\"Frank\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:18:{i:0;s:20:\"DISCAFANI, Carolyn M\";i:1;s:27:\"SINGANALLORE, Thiruvikraman\";i:2;s:17:\"KHAFIZOVA, Gulnaz\";i:3;s:23:\"PORUCHYNSKY, Marianne S\";i:4;s:10:\"FOJO, Tito\";i:5;s:15:\"NIEMAN, James A\";i:6;s:27:\"AYRAL-KALOUSTIAN, Semiramis\";i:7;s:10:\"ZASK, Arie\";i:8;s:19:\"ANDERSEN, Raymond J\";i:9;s:18:\"GREENBERGER, Lee M\";i:10;s:13:\"ANNABLE, Tami\";i:11;s:11:\"BEYER, Carl\";i:12;s:13:\"MUSTO, Sylvia\";i:13;s:13:\"HARI, Malathi\";i:14;s:11:\"XINGZHI TAN\";i:15;s:14:\"HARDY, Carolyn\";i:16;s:18:\"HERNANDEZ, Richard\";i:17;s:16:\"BAXTER, Michelle\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:0:\"\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:9:\"\u0000*\u0000jtitle\";s:27:\"Cancer research (Baltimore)\";s:9:\"\u0000*\u0000stitle\";s:23:\"Cancer res. (Baltimore)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"63\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:4:\"1838\";s:8:\"\u0000*\u0000epage\";s:4:\"1845\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0008-5472\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"LOGANZO\";s:10:\"\u0000*\u0000aufirst\";s:5:\"Frank\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:18:{i:0;s:20:\"DISCAFANI, Carolyn M\";i:1;s:27:\"SINGANALLORE, Thiruvikraman\";i:2;s:17:\"KHAFIZOVA, Gulnaz\";i:3;s:23:\"PORUCHYNSKY, Marianne S\";i:4;s:10:\"FOJO, Tito\";i:5;s:15:\"NIEMAN, James A\";i:6;s:27:\"AYRAL-KALOUSTIAN, Semiramis\";i:7;s:10:\"ZASK, Arie\";i:8;s:19:\"ANDERSEN, Raymond J\";i:9;s:18:\"GREENBERGER, Lee M\";i:10;s:13:\"ANNABLE, Tami\";i:11;s:11:\"BEYER, Carl\";i:12;s:13:\"MUSTO, Sylvia\";i:13;s:13:\"HARI, Malathi\";i:14;s:11:\"XINGZHI TAN\";i:15;s:14:\"HARDY, Carolyn\";i:16;s:18:\"HERNANDEZ, Richard\";i:17;s:16:\"BAXTER, Michelle\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"CNREA8\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:168:\"HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo\";s:8:\"\u0000*\u0000place\";s:16:\"Philadelphia, PA\";s:6:\"\u0000*\u0000pub\";s:40:\"American Association for Cancer Research\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
