Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to taxol
- Author
- SOLIT, David B1 2 ; BASSO, Andrea D2 ; OLSHEN, Adam B3 ; SCHER, Howard I1 ; ROSEN, Neal1 2
[1] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York New York 10021, United States
[2] Program in Cell Biology, Memorial Sloan-Kettering Cancer Center, New York New York 10021, United States
[3] Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York New York 10021, United States - Source
Cancer research (Baltimore). 2003, Vol 63, Num 9, pp 2139-2144, 6 p ; ref : 34 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Activité enzymatique Animal Anticancéreux Association médicamenteuse Cellule tumorale Chimiosensibilisant Chimiothérapie Glande mammaire Homme In vitro In vivo Lignée cellulaire établie Mécanisme action Paclitaxel Protein kinase Protéine choc thermique Souris Taxane dérivé Traitement Tumeur maligne 17 AAG Ansamycines Geldanamycine dérivé Protein kinase AKT Protein kinase B Protéine hsp90 Enzyme Glande mammaire pathologie Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Biological activity Enzymatic activity Animal Antineoplastic agent Drug combination Tumor cell Chemosensitizing agent Chemotherapy Mammary gland Human In vitro In vivo Established cell line Mechanism of action Paclitaxel Protein kinase Heat shock protein Mouse Taxane derivatives Treatment Malignant tumor Protein kinase B Heat shock protein 90 Enzyme Mammary gland diseases Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Actividad biológica Actividad enzimática Animal Anticanceroso Asociación medicamentosa Célula tumoral Quimiosensibilizante Quimioterapia Glándula mamaria Hombre In vitro In vivo Línea celular establecida Mecanismo acción Paclitaxel Protein kinase Proteína choque térmico Ratón Taxane derivado Tratamiento Tumor maligno Enzima Glándula mamaria patología Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14747347
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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