ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells
- Author
- ANIDO, Judit1 ; MATAR, Pablo1 ; ALBANELL, Joan1 ; GUZMAN, Marta1 ; ROJO, Federico1 ; ARRIBAS, Joaquin1 ; AVERBUCH, Steve2 ; BASELGA, Jose1 3
[1] Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona 08035, Spain
[2] AstraZeneca Pharmaceuticals, Wilmington, Delaware, United States
[3] Universidad Autonoma de Barcelona, Barcelona, Spain - Source
Clinical cancer research. 2003, Vol 9, Num 4, pp 1274-1283, 10 p ; ref : 56 ref
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Cellule tumorale Glande mammaire Hétérodimère In vitro Inhibiteur Neuréguline Protein-tyrosine kinase Surexpression génique Transduction signal Récepteur EGFR Enzyme Transferases
- Keyword (en)
- Biological activity Antineoplastic agent Tumor cell Mammary gland Heterodimer In vitro Inhibitor Neuregulin Protein-tyrosine kinase Gene overexpression Signal transduction Epidermal growth factor receptor Enzyme Transferases
- Keyword (es)
- Actividad biológica Anticanceroso Célula tumoral Glándula mamaria Heterodimero In vitro Inhibidor Neuregulina Protein-tyrosine kinase Sobreexpressión genética Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14770859
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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