Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids
- Author
- SAGI, Kazuyuki1 ; NAKAGAWA, Tadakiyo1 ; ISHIKAWA, Kohki1 ; SHIMA, Sayaka1 ; FUKUDA, Yumiko1 ; KAYAHARA, Takashi1 ; TAKEHANA, Shunji1 ; SHIMA, Yoichiro1 ; TASHIRO, Kazumi1 ; YAMAMOTO, Hiroshi1 ; YOSHIMOTO, Ryota1 ; IWATA, Seinosuke1 ; YAMANASHI, Masahiro1 ; TSUJI, Takashi2 ; SAKURAI, Kuniya2 ; SHOJI, Masataka2 ; MAKINO, Shingo1 ; TAKAHASHI, Mitsuo1 ; TAKAYANAGI, Masaru1 ; TAKENAKA, Kaoru1 ; SUZUKI, Nobuyasu1 ; OONO, Seiji1 ; KATAOKA, Noriyasu1
[1] Pharmaceutical Research Laboratories, Ajinomoto Company Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681, Japan
[2] Pharmaceutical Research Laboratories, Ajinomoto Company Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681, Japan - Source
Journal of medicinal chemistry (Print). 2003, Vol 46, Num 10, pp 1845-1857, 13 p ; ref : 29 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Amidine Animal Anticoagulant Benzamide dérivé Biodisponibilité Carboxamide Coagulation Factor Xa Complexe enzyme inhibiteur Composé non peptide Cétoacide Ether Homme In vitro In vivo Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Pharmacocinétique Pyridine dérivé Relation structure activité Singe Synthèse chimique Sélectivité Voie orale Benzamidine dérivé Benzènepropionique acide4-amidino-2-[2-([1-(1-[4-pyridyl]pipéridin-4-yl)carbonyl]amino)éthoxy] Benzènepyruvique acide(2-[2-(4-[1-acétimidoylpipéridin-4-yloxy]benzamido)-4-carboxybutoxy]-4-amidino) Pipéridine-4-carboxamide dérivé Enzyme Hydrolases Mammalia Peptidases Primates Serine endopeptidases Vertebrata
- Keyword (en)
- Carboxylic acid Amidine Animal Anticoagulant Benzamide derivatives Bioavailability Carboxamide Coagulation Factor Xa Inhibitor enzyme complex Non peptide compound Ketoacid Ether Human In vitro In vivo Enzyme inhibitor Binding mode Molecular model Modeling Pharmacokinetics Pyridine derivatives Structure activity relation Monkey Chemical synthesis Selectivity Oral administration Enzyme Hydrolases Mammalia Peptidases Primates Serine endopeptidases Vertebrata
- Keyword (es)
- Acido carboxílico Amidina Animal Anticoagulante Benzamida derivado Biodisponibilidad Carboxamida Coagulation Factor Xa Complejo enzima inhibidor Compuesto no péptido Cetoácido Eter Hombre In vitro In vivo Inhibidor enzima Modo de enlace Modelo molecular Modelización Farmacocinética Piridina derivado Relación estructura actividad Mono Síntesis química Selectividad Vía oral Enzima Hydrolases Mammalia Peptidases Primates Serine endopeptidases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14788074
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm020485x 
https://dx.doi.org/10.1021/jm020485x
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"46\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"1845\";s:8:\"\u0000*\u0000epage\";s:4:\"1857\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"SAGI\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Kazuyuki\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:22:{i:0;s:18:\"NAKAGAWA, Tadakiyo\";i:1;s:15:\"ISHIKAWA, Kohki\";i:2;s:13:\"SHIMA, Sayaka\";i:3;s:14:\"FUKUDA, Yumiko\";i:4;s:17:\"KAYAHARA, Takashi\";i:5;s:16:\"TAKEHANA, Shunji\";i:6;s:15:\"SHIMA, Yoichiro\";i:7;s:15:\"TASHIRO, Kazumi\";i:8;s:17:\"YAMAMOTO, Hiroshi\";i:9;s:16:\"YOSHIMOTO, Ryota\";i:10;s:16:\"IWATA, Seinosuke\";i:11;s:19:\"YAMANASHI, Masahiro\";i:12;s:14:\"TSUJI, Takashi\";i:13;s:15:\"SAKURAI, Kuniya\";i:14;s:15:\"SHOJI, Masataka\";i:15;s:14:\"MAKINO, Shingo\";i:16;s:17:\"TAKAHASHI, Mitsuo\";i:17;s:18:\"TAKAYANAGI, Masaru\";i:18;s:15:\"TAKENAKA, Kaoru\";i:19;s:16:\"SUZUKI, Nobuyasu\";i:20;s:11:\"OONO, Seiji\";i:21;s:17:\"KATAOKA, Noriyasu\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"46\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"1845\";s:8:\"\u0000*\u0000epage\";s:4:\"1857\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"SAGI\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Kazuyuki\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:22:{i:0;s:18:\"NAKAGAWA, Tadakiyo\";i:1;s:15:\"ISHIKAWA, Kohki\";i:2;s:13:\"SHIMA, Sayaka\";i:3;s:14:\"FUKUDA, Yumiko\";i:4;s:17:\"KAYAHARA, Takashi\";i:5;s:16:\"TAKEHANA, Shunji\";i:6;s:15:\"SHIMA, Yoichiro\";i:7;s:15:\"TASHIRO, Kazumi\";i:8;s:17:\"YAMAMOTO, Hiroshi\";i:9;s:16:\"YOSHIMOTO, Ryota\";i:10;s:16:\"IWATA, Seinosuke\";i:11;s:19:\"YAMANASHI, Masahiro\";i:12;s:14:\"TSUJI, Takashi\";i:13;s:15:\"SAKURAI, Kuniya\";i:14;s:15:\"SHOJI, Masataka\";i:15;s:14:\"MAKINO, Shingo\";i:16;s:17:\"TAKAHASHI, Mitsuo\";i:17;s:18:\"TAKAYANAGI, Masaru\";i:18;s:15:\"TAKENAKA, Kaoru\";i:19;s:16:\"SUZUKI, Nobuyasu\";i:20;s:11:\"OONO, Seiji\";i:21;s:17:\"KATAOKA, Noriyasu\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"46\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"1845\";s:8:\"\u0000*\u0000epage\";s:4:\"1857\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"SAGI\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Kazuyuki\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:22:{i:0;s:18:\"NAKAGAWA, Tadakiyo\";i:1;s:15:\"ISHIKAWA, Kohki\";i:2;s:13:\"SHIMA, Sayaka\";i:3;s:14:\"FUKUDA, Yumiko\";i:4;s:17:\"KAYAHARA, Takashi\";i:5;s:16:\"TAKEHANA, Shunji\";i:6;s:15:\"SHIMA, Yoichiro\";i:7;s:15:\"TASHIRO, Kazumi\";i:8;s:17:\"YAMAMOTO, Hiroshi\";i:9;s:16:\"YOSHIMOTO, Ryota\";i:10;s:16:\"IWATA, Seinosuke\";i:11;s:19:\"YAMANASHI, Masahiro\";i:12;s:14:\"TSUJI, Takashi\";i:13;s:15:\"SAKURAI, Kuniya\";i:14;s:15:\"SHOJI, Masataka\";i:15;s:14:\"MAKINO, Shingo\";i:16;s:17:\"TAKAHASHI, Mitsuo\";i:17;s:18:\"TAKAYANAGI, Masaru\";i:18;s:15:\"TAKENAKA, Kaoru\";i:19;s:16:\"SUZUKI, Nobuyasu\";i:20;s:11:\"OONO, Seiji\";i:21;s:17:\"KATAOKA, Noriyasu\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"46\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"1845\";s:8:\"\u0000*\u0000epage\";s:4:\"1857\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"SAGI\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Kazuyuki\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:22:{i:0;s:18:\"NAKAGAWA, Tadakiyo\";i:1;s:15:\"ISHIKAWA, Kohki\";i:2;s:13:\"SHIMA, Sayaka\";i:3;s:14:\"FUKUDA, Yumiko\";i:4;s:17:\"KAYAHARA, Takashi\";i:5;s:16:\"TAKEHANA, Shunji\";i:6;s:15:\"SHIMA, Yoichiro\";i:7;s:15:\"TASHIRO, Kazumi\";i:8;s:17:\"YAMAMOTO, Hiroshi\";i:9;s:16:\"YOSHIMOTO, Ryota\";i:10;s:16:\"IWATA, Seinosuke\";i:11;s:19:\"YAMANASHI, Masahiro\";i:12;s:14:\"TSUJI, Takashi\";i:13;s:15:\"SAKURAI, Kuniya\";i:14;s:15:\"SHOJI, Masataka\";i:15;s:14:\"MAKINO, Shingo\";i:16;s:17:\"TAKAHASHI, Mitsuo\";i:17;s:18:\"TAKAYANAGI, Masaru\";i:18;s:15:\"TAKENAKA, Kaoru\";i:19;s:16:\"SUZUKI, Nobuyasu\";i:20;s:11:\"OONO, Seiji\";i:21;s:17:\"KATAOKA, Noriyasu\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm020485x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2003\";s:9:\"\u0000*\u0000volume\";s:2:\"46\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"1845\";s:8:\"\u0000*\u0000epage\";s:4:\"1857\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"SAGI\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Kazuyuki\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:22:{i:0;s:18:\"NAKAGAWA, Tadakiyo\";i:1;s:15:\"ISHIKAWA, Kohki\";i:2;s:13:\"SHIMA, Sayaka\";i:3;s:14:\"FUKUDA, Yumiko\";i:4;s:17:\"KAYAHARA, Takashi\";i:5;s:16:\"TAKEHANA, Shunji\";i:6;s:15:\"SHIMA, Yoichiro\";i:7;s:15:\"TASHIRO, Kazumi\";i:8;s:17:\"YAMAMOTO, Hiroshi\";i:9;s:16:\"YOSHIMOTO, Ryota\";i:10;s:16:\"IWATA, Seinosuke\";i:11;s:19:\"YAMANASHI, Masahiro\";i:12;s:14:\"TSUJI, Takashi\";i:13;s:15:\"SAKURAI, Kuniya\";i:14;s:15:\"SHOJI, Masataka\";i:15;s:14:\"MAKINO, Shingo\";i:16;s:17:\"TAKAHASHI, Mitsuo\";i:17;s:18:\"TAKAYANAGI, Masaru\";i:18;s:15:\"TAKENAKA, Kaoru\";i:19;s:16:\"SUZUKI, Nobuyasu\";i:20;s:11:\"OONO, Seiji\";i:21;s:17:\"KATAOKA, Noriyasu\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:155:\"Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-Substituted-4-amidinophenyl)pyruvic and -propionic acids\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
