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A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides

Author
BACHI, Mario D1 ; KORSHIN, Edward E1 ; HOOS, Roland1 ; SZPILMAN, Alex M1 ; PLOYPRADITH, Poonsakdi2 ; SUJI XIE3 ; SHAPIRO, Theresa A3 ; POSNER, Gary H2
[1] Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
[2] Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, United States
[3] Division of Clinical Pharmacology, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, United States
Source

Journal of medicinal chemistry (Print). 2003, Vol 46, Num 12, pp 2516-2533, 18 p ; ref : 53 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Acylate Animal Antipaludique Antiparasitaire Composé bicyclique Endoperoxyde Hétérocycle oxygène In vitro In vivo Peroxyde organique Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Relation structure activité Souris Sulfone Synthèse chimique 2,3-Dioxabicyclo[3.3.1]nonan-7-ol(4-benzènesulfonylméthyl-4,7-diméthyl) acétate 2,3-Dioxabicyclo[3.3.1]nonane(4-benzènesulfonylméthyl-7-benzyloxy-4,7-diméthyl) Dioxabicyclononane Apicomplexa Mammalia Protozoa Rodentia Vertebrata
Keyword (en)
Acylate Animal Antimalarial Parasiticid Bicyclic compound Endoperoxide Oxygen heterocycle In vitro In vivo Organic peroxide Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Structure activity relation Mouse Sulfone Chemical synthesis Apicomplexa Mammalia Protozoa Rodentia Vertebrata
Keyword (es)
Acilato Animal Antipalúdico Antiparasitario Compuesto bicíclico Endoperóxido Heterociclo oxígeno In vitro In vivo Peróxido orgánico Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Relación estructura actividad Ratón Sulfona Síntesis química Apicomplexa Mammalia Protozoa Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
14843786

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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